Detailed information of TA system TA141144

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 23972..24525
• Replicon: plasmid pLG24p1
• Accession: NZ_CP045053
• Organism: Salmonella enterica subsp. enterica serovar Muenchen strain LG24

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: SMLG24_RS00145
• Protein ID: WP_057394242.1
• Coordinates: 23972..24286 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: SMLG24_RS00150
• Protein ID: WP_057394243.1
• Coordinates: 24289..24525 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SMLG24_RS00115	20420..20677	-	258	WP_153789508.1	hypothetical protein	-
SMLG24_RS00120	20701..20934	-	234	WP_004178129.1	hypothetical protein	-
SMLG24_RS00125	20975..21622	-	648	WP_153789509.1	ParA family protein	-
SMLG24_RS00130	21742..22524	-	783	WP_153789510.1	sprT domain-containing protein	-
SMLG24_RS00135	22960..23238	+	279	WP_048044186.1	type II toxin-antitoxin system HicA family toxin	-
SMLG24_RS00140	23231..23578	+	348	WP_153789511.1	type II toxin-antitoxin system HicB family antitoxin	-
SMLG24_RS00145	23972..24286	-	315	WP_057394242.1	CcdB family protein	Toxin
SMLG24_RS00150	24289..24525	-	237	WP_057394243.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
SMLG24_RS00155	24636..24869	-	234	WP_153789512.1	XRE family transcriptional regulator	-
SMLG24_RS00160	24859..25116	-	258	WP_153789513.1	hypothetical protein	-
SMLG24_RS00165	25113..25313	-	201	WP_153789514.1	hypothetical protein	-
SMLG24_RS00170	25427..25942	-	516	WP_153789515.1	J domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..26060	26060

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 15471.56 Da
• Isoelectric Point: 5.5500

>T141144 WP_057394242.1 NZ_CP045053:c24286-23972 [Salmonella enterica subsp. enterica serovar Muenchen]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 315 bp

>T141144 NZ_CP059838:37867-38148 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 11644.97 Da
• Isoelectric Point: 5.5500

>AT141144 WP_057394243.1 NZ_CP045053:c24525-24289 [Salmonella enterica subsp. enterica serovar Muenchen]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 237 bp

>AT141144 NZ_CP059838:37626-37877 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
AGGAACTCGCTGAAAATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA