141143

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 491689..492338 Replicon chromosome
Accession NZ_CP045051
Organism Acinetobacter johnsonii strain AJ312

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GBN67_RS02460 Protein ID WP_234963497.1
Coordinates 491919..492338 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D0SB20
Locus tag GBN67_RS02455 Protein ID WP_005400268.1
Coordinates 491689..491919 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GBN67_RS02435 (GBN67_02430) 486939..487661 - 723 WP_183174150.1 folate-binding Fe/S cluster repair protein -
GBN67_RS02440 (GBN67_02435) 487923..490529 + 2607 WP_234963495.1 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
GBN67_RS02445 (GBN67_02440) 490606..490947 + 342 WP_126037799.1 hypothetical protein -
GBN67_RS02450 (GBN67_02445) 491051..491584 + 534 WP_234963496.1 hypothetical protein -
GBN67_RS02455 (GBN67_02450) 491689..491919 + 231 WP_005400268.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GBN67_RS02460 (GBN67_02455) 491919..492338 + 420 WP_234963497.1 type II toxin-antitoxin system VapC family toxin Toxin
GBN67_RS02465 (GBN67_02460) 492469..492612 + 144 WP_004695201.1 zinc ribbon-containing protein -
GBN67_RS02470 (GBN67_02465) 492732..493307 + 576 WP_234963498.1 DUF4126 domain-containing protein -
GBN67_RS02475 (GBN67_02470) 493540..493746 + 207 WP_004695205.1 hypothetical protein -
GBN67_RS02480 (GBN67_02475) 493828..494181 - 354 WP_234963499.1 hypothetical protein -
GBN67_RS02485 (GBN67_02480) 494396..495094 + 699 WP_234963500.1 hypothetical protein -
GBN67_RS02490 (GBN67_02485) 495202..495474 + 273 WP_234963501.1 hypothetical protein -
GBN67_RS02495 (GBN67_02490) 496064..496459 + 396 WP_010327416.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 16148.54 Da        Isoelectric Point: 6.2193

>T141143 WP_234963497.1 NZ_CP045051:491919-492338 [Acinetobacter johnsonii]
MQTQYLLDTNICIYIIKHQPEIVRQHFEKHLPHRNILISVITLGELRFGAEKSQQKEKALKVIDELTSMIQVVELDEYVA
DHYAQIRQDLSSKGQIIGANDLWLAAHARANNWVMVTNNEKEFLRVDGLQIENWVSNIL

Download         Length: 420 bp

>T141143 NZ_CP059837:c124198-124046 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGTACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 9037.30 Da        Isoelectric Point: 4.7049

>AT141143 WP_005400268.1 NZ_CP045051:491689-491919 [Acinetobacter johnsonii]
MTTAKVFMTGRSQAVRLPKEFRFEGTEVEIFRRGDEVILREKPVTVDRLFKVLAQMPNDFYAEERVDEPPQEREEF

Download         Length: 231 bp

>AT141143 NZ_CP059837:124248-124310 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8XEV0

References