Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 785518..786175 Replicon chromosome
Accession NZ_CP045015
Organism Klebsiella pneumoniae subsp. pneumoniae strain BK13048

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag F9865_RS03940 Protein ID WP_002916310.1
Coordinates 785765..786175 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag F9865_RS03935 Protein ID WP_002916312.1
Coordinates 785518..785784 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9865_RS03910 780674..782107 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
F9865_RS03915 782226..782954 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
F9865_RS03920 783004..783315 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
F9865_RS03925 783479..784138 + 660 WP_002916317.1 hemolysin III family protein -
F9865_RS03930 784289..785272 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
F9865_RS03935 785518..785784 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
F9865_RS03940 785765..786175 + 411 WP_002916310.1 protein YgfX Toxin
F9865_RS03945 786182..786703 - 522 WP_004144730.1 flavodoxin FldB -
F9865_RS03950 786804..787700 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
F9865_RS03955 787723..788436 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
F9865_RS03960 788442..790175 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T141104 WP_002916310.1 NZ_CP045015:785765-786175 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T141104 NZ_CP059794:c214056-213784 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT141104 WP_002916312.1 NZ_CP045015:785518-785784 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT141104 NZ_CP059794:c214319-214056 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References