Detailed information of TA system TA141096

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3926547..3927246
• Replicon: chromosome
• Accession: NZ_CP045008
• Organism: Proteus terrae subsp. cibarius strain ZF2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F9282_RS18425
• Protein ID: WP_075671320.1
• Coordinates: 3926547..3926933 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F9282_RS18430
• Protein ID: WP_075671318.1
• Coordinates: 3926926..3927246 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9282_RS18410	3922585..3923169	-	585	WP_075671324.1	DNA-3-methyladenine glycosylase I	-
F9282_RS18415	3923408..3924313	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
F9282_RS18420	3924323..3926395	+	2073	WP_075671322.1	glycine--tRNA ligase subunit beta	-
F9282_RS18425	3926547..3926933	+	387	WP_075671320.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F9282_RS18430	3926926..3927246	+	321	WP_075671318.1	helix-turn-helix domain-containing protein	Antitoxin
F9282_RS18435	3927314..3927634	-	321	WP_075671316.1	hypothetical protein	-
F9282_RS18440	3927740..3929026	-	1287	WP_075671314.1	DUF3748 domain-containing protein	-
F9282_RS18445	3929163..3929780	+	618	WP_006534609.1	trimeric intracellular cation channel family protein	-
F9282_RS18450	3930086..3930709	+	624	WP_006534608.1	guanylate kinase	-
F9282_RS18455	3930764..3931039	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (50-96)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14358.75 Da
• Isoelectric Point: 10.0463

>T141096 WP_075671320.1 NZ_CP045008:3926547-3926933 [Proteus terrae subsp. cibarius]
MVIYKTKMFKNSFKKMPINDAALIDIANEVYAGHFEADLGGGIIKKRICIHGKGKSSGIRTIIFYKQGSNLFFADGWKKS
HLSAKKSKEITDDELESYKDLAKDLFSATKNKIDKMVALGLLTEVKHD

Nucleotide

• Length: 387 bp

>T141096 NZ_CP059773:c156840-155977 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTC
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGCG
AAACTTTATGAGAAAGACGTAGTAAAACACGTCACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGCTATAATTTAGTGATTGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTTATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACTATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTTTACAATAGAGAAGGAGTGAAACTCTATTCAA
GATTAGAAACGCCTTCTATTAGTCCGAAAGAGACCTTAGAAAGAGAATTAAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTGGAGAGAATAGAGCAAAAAATGCTTCAAAATCAACACCAAGAAACCCCTGAATTTAAAGCAATTCAACAAAA
AATGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12068.99 Da
• Isoelectric Point: 10.0482

>AT141096 WP_075671318.1 NZ_CP045008:3926926-3927246 [Proteus terrae subsp. cibarius]
MTDKMQEMLKFAQEMEVAGITDGESARRIAARIKAKELKERYAHLTPMNGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLNLIDNKAISI

Nucleotide

• Length: 321 bp

>AT141096 NZ_CP059773:c157114-156842 [Enterococcus faecium]
ATGGCAGTTACATATGAAAAAACATTTGAAATTGAAATCATTAATGAGTTATCGGCAAGTGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA