Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3572517..3574264 Replicon chromosome
Accession NZ_CP045008
Organism Proteus terrae subsp. cibarius strain ZF2

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag F9282_RS16775 Protein ID WP_098941872.1
Coordinates 3572517..3573890 (+) Length 458 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag F9282_RS16780 Protein ID WP_098941871.1
Coordinates 3573887..3574264 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9282_RS16760 3568189..3569172 - 984 WP_075673449.1 ABC transporter permease -
F9282_RS16765 3569157..3570740 - 1584 WP_156734135.1 ABC transporter substrate-binding protein -
F9282_RS16770 3571145..3572134 - 990 WP_156734136.1 glycosyltransferase -
F9282_RS16775 3572517..3573890 + 1374 WP_098941872.1 type II toxin-antitoxin system HipA family toxin Toxin
F9282_RS16780 3573887..3574264 + 378 WP_098941871.1 helix-turn-helix domain-containing protein Antitoxin
F9282_RS16785 3574386..3574886 - 501 WP_075673444.1 hydrogenase maturation peptidase HycI -
F9282_RS16790 3574883..3575293 - 411 WP_088494545.1 formate hydrogenlyase maturation HycH family protein -
F9282_RS16795 3575286..3576068 - 783 WP_099659719.1 NADH-quinone oxidoreductase subunit B family protein -
F9282_RS16800 3576065..3576619 - 555 WP_075673442.1 hydrogenase 4 subunit H -
F9282_RS16805 3576631..3578364 - 1734 WP_075673441.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(174-418)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-103)


Sequences

Toxin        


Download         Length: 458 a.a.        Molecular weight: 52589.44 Da        Isoelectric Point: 4.6415

>T141094 WP_098941872.1 NZ_CP045008:3572517-3573890 [Proteus terrae subsp. cibarius]
MEKITLQAFLNQEWVDIAIINFPKYDRMLYASKYDITYPITELEYETSYSIEHLYQDDQHAVSINHPVELYFDDSGSPGW
LKFLDDIVPSGASRRYWLQYLDIAELSTEQQNYELLHHGTISPIGNLRVKESLPAPSPLNRNLFFTINDVKNRASDFLDY
AQRKGAAAGGATGAGGEAPKLLLRCNDNEEVWIDTYQDDISNLDKYYLVKFPRGSRSVVDCNILRTEYHFYHELTDMGFD
TIPIKDMRLEEGDNYPSLWLPRFDIKIENNKIIRLAMESVYSILNKAPGTTLYHETVIKELIDKINQSNMVTEFGFQFNT
ANFIIEWVRRDLLNIIFGNSDNHGRNTSLIRYNNAIYLAPIYDFAPMKADPEGIARTTKWGSHSEIGGEYNFINIADSLS
DLIAPEQLLNALQETAQQLLTLKERLEMRGVPTQILTMPSFGFDFIPNKLERWGLLP

Download         Length: 1374 bp

>T141094 NZ_CP059772:189937-190203 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14108.43 Da        Isoelectric Point: 10.5220

>AT141094 WP_098941871.1 NZ_CP045008:3573887-3574264 [Proteus terrae subsp. cibarius]
MNNVENKNHIDKFPTRASRKHQFVATTDRKQVISKIMAHLLFGEITQGEALKMLRIKVLGLNQDLYAKLINVSRKTLSEI
ENDRGNYSADIINKVFKPFGLKVGLVPSSPHILSSLLKESPPINE

Download         Length: 378 bp

>AT141094 NZ_CP059772:189674-189937 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References