Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/GNAT-DUF1778
Location 2467953..2468698 Replicon chromosome
Accession NZ_CP045008
Organism Proteus terrae subsp. cibarius strain ZF2

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag F9282_RS11850 Protein ID WP_075673025.1
Coordinates 2468207..2468698 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag F9282_RS11845 Protein ID WP_075673024.1
Coordinates 2467953..2468219 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9282_RS11810 2463616..2464098 + 483 WP_006533151.1 flagellar basal body-associated protein FliL -
F9282_RS11815 2464104..2465132 + 1029 WP_088495228.1 flagellar motor switch protein FliM -
F9282_RS11820 2465125..2465535 + 411 WP_023581830.1 flagellar motor switch protein FliN -
F9282_RS11825 2465539..2465985 + 447 WP_023581829.1 flagellar biosynthetic protein FliO -
F9282_RS11830 2466042..2466755 + 714 WP_171455369.1 flagellar type III secretion system pore protein FliP -
F9282_RS11835 2466771..2467040 + 270 WP_069367481.1 flagellar biosynthesis protein FliQ -
F9282_RS11840 2467046..2467828 + 783 WP_088495227.1 flagellar type III secretion system protein FliR -
F9282_RS11845 2467953..2468219 + 267 WP_075673024.1 DUF1778 domain-containing protein Antitoxin
F9282_RS11850 2468207..2468698 + 492 WP_075673025.1 GNAT family N-acetyltransferase Toxin
F9282_RS11855 2468784..2469728 - 945 WP_156733628.1 flagellar hook-associated protein FlgL -
F9282_RS11860 2469760..2471403 - 1644 WP_156733630.1 flagellar hook-associated protein FlgK -
F9282_RS11865 2471521..2472507 - 987 WP_088495222.1 flagellar assembly peptidoglycan hydrolase FlgJ -
F9282_RS11870 2472507..2473613 - 1107 WP_088495221.1 flagellar basal body P-ring protein FlgI -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(22-150)

Antitoxin

(2-87)


Sequences


Toxin        


Download         Length: 164 a.a.        Molecular weight: 18228.15 Da        Isoelectric Point: 10.3194

>T141093 WP_075673025.1 NZ_CP045008:2468207-2468698 [Proteus terrae subsp. cibarius]
MGKVTAPEPLSNSHEVADFYSSENVLDNWIKQRGLKNQFLGASRTFVVCEKNKKRVVGYYSLATGSVNHTEAMSHIRRNM
PDPIPVIILARLAVDKTFHGKGLGADLLRDAVLRCHHVAENIGVRAIMVHALTENAKHFYLHHGFKASSTQDKILFLALK
KKI

Download         Length: 492 bp

>T141093 NZ_CP059767:c22869-22612 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10111.62 Da        Isoelectric Point: 4.5256

>AT141093 WP_075673024.1 NZ_CP045008:2467953-2468219 [Proteus terrae subsp. cibarius]
MKADVQLNIRAKESQRALIDTAAEILHKSRTDFILETACQAAEDVILDRRTFNLNDAQYAEFIEIIDAPVDIDPALEKLL
MRKPLWEK

Download         Length: 267 bp

>AT141093 NZ_CP059767:c23131-22862 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References