Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 482189..483105 Replicon plasmid pPAG5
Accession NZ_CP045003
Organism Pseudomonas aeruginosa strain PAG5

Toxin (Protein)


Gene name slvT Uniprot ID A0A212BIN6
Locus tag F9C43_RS33930 Protein ID WP_021018402.1
Coordinates 482189..482713 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2I0C738
Locus tag F9C43_RS33935 Protein ID WP_010792483.1
Coordinates 482710..483105 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9C43_RS33905 477647..477838 - 192 WP_010792486.1 hypothetical protein -
F9C43_RS33910 478216..479001 + 786 WP_165567237.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
F9C43_RS33915 479091..480390 + 1300 Protein_545 ISL3-like element IS1411 family transposase -
F9C43_RS33920 480409..480696 + 288 WP_165567238.1 hypothetical protein -
F9C43_RS33925 480893..482143 + 1251 WP_010792484.1 TerD family protein -
F9C43_RS33930 482189..482713 - 525 WP_021018402.1 RES family NAD+ phosphorylase Toxin
F9C43_RS33935 482710..483105 - 396 WP_010792483.1 hypothetical protein Antitoxin
F9C43_RS33940 483315..485198 - 1884 WP_060616973.1 hypothetical protein -
F9C43_RS33945 486546..487070 + 525 WP_010794447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aph(3')-Ia / mph(E) / msr(E) / sul1 / qacE / catB3 / blaOXA-1 / blaIMP-45 / dfrA22 / ARR-3 / qnrVC1 - 1..513322 513322
- flank IS/Tn - - 479689..480390 701


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19011.47 Da        Isoelectric Point: 4.4540

>T141091 WP_021018402.1 NZ_CP045003:c482713-482189 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQGSAFLPPGLLVSYSLSLDRVI
DFTGGYDDTWAPIWQDFFCDWRKIRFNDGVEPPSWIVGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T141091 NZ_CP059765:51071-51328 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14810.93 Da        Isoelectric Point: 7.2048

>AT141091 WP_010792483.1 NZ_CP045003:c483105-482710 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFNYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT141091 NZ_CP059765:50809-51078 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A212BIN6

Antitoxin

Source ID Structure
AlphaFold DB A0A2I0C738

References