Detailed information of TA system TA141089

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 5440820..5441367
• Replicon: chromosome
• Accession: NZ_CP045002
• Organism: Pseudomonas aeruginosa strain PAG5

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F9C43_RS25325
• Protein ID: WP_121496487.1
• Coordinates: 5440820..5441095 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F9C43_RS25330
• Protein ID: WP_121496486.1
• Coordinates: 5441095..5441367 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9C43_RS25300	5436113..5437159	-	1047	WP_121496492.1	NAD(P)-dependent oxidoreductase	-
F9C43_RS25305	5437152..5437826	-	675	WP_124083107.1	hypothetical protein	-
F9C43_RS25310	5437838..5438320	-	483	WP_121496490.1	adenylyltransferase/cytidyltransferase family protein	-
F9C43_RS25315	5438328..5438831	-	504	WP_121496489.1	GNAT family N-acetyltransferase	-
F9C43_RS25320	5438821..5440134	-	1314	WP_162950080.1	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	-
F9C43_RS25325	5440820..5441095	-	276	WP_121496487.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F9C43_RS25330	5441095..5441367	-	273	WP_121496486.1	ribbon-helix-helix domain-containing protein	Antitoxin
F9C43_RS25335	5441627..5442187	+	561	WP_023102601.1	recombinase family protein	-
F9C43_RS25340	5442244..5442969	-	726	WP_188129804.1	hypothetical protein	-
F9C43_RS25345	5443001..5443666	-	666	WP_121496494.1	DUF3218 family protein	-
F9C43_RS25350	5443677..5444708	-	1032	WP_121496485.1	hypothetical protein	-
F9C43_RS25355	5445052..5446032	-	981	WP_010466230.1	IS5-like element IS1384 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	5382594..5486087	103493

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (10-47)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10688.33 Da
• Isoelectric Point: 10.4249

>T141089 WP_121496487.1 NZ_CP045002:c5441095-5440820 [Pseudomonas aeruginosa]
MELKWTNKGLSDLTRLYEFLAAVNRSAAARTVQQLTSAPTKLLANPRIGERLEEFDPRDVRRILVGHYEMRYEIAGSTIY
LLRLWHTRKDR

Nucleotide

• Length: 276 bp

>T141089 NZ_CP059764:c1791165-1790932 [Enterococcus faecium]
ATAACGTGTAATTTAGGGAAGTGTTTGTGGTATAATAACAGAACAGTAAAGTTTGTGACGGTGGCTATCTTTTGGAAGGT
GGTGGTGCTTATGGAAGTAAGTGTTCACTCTTTAGAAAGGAGAAGCCTTTTGTCTGTAGCTGAAGCATTAGGATTAATGA
TTAGTTTCGGTTCTTTAATCGCAACAATCATTTTCGGTATCCTAACTGCAGTGAAAAATGACAAGAAAAAATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10131.35 Da
• Isoelectric Point: 4.5127

>AT141089 WP_121496486.1 NZ_CP045002:c5441367-5441095 [Pseudomonas aeruginosa]
MPANAKTRSVTAHVPIELAERVDDIAERLERSKNWIVKQALTAWLDQEDERSRLTREALVDVDDGCVIDHQAVQAWADSL
STDTPLPVPR

Nucleotide

• Length: 273 bp

>AT141089 NZ_CP059764:1790866-1790952 [Enterococcus faecium]
CCGCTTAAGACGGTGGCGACATTAGTTATATCTAAAAAATAACCGCTGACTCGCTAAAGTAGACGGTTATTTTTTCTTGT
CATTTTT