Detailed information of TA system TA141088

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4627601..4628858
• Replicon: chromosome
• Accession: NZ_CP045002
• Organism: Pseudomonas aeruginosa strain PAG5

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: F9C43_RS21540
• Protein ID: WP_003449003.1
• Coordinates: 4627601..4628356 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: F9C43_RS21545
• Protein ID: WP_003086329.1
• Coordinates: 4628490..4628858 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9C43_RS21530	4622774..4625317	+	2544	WP_003140632.1	acyl-homoserine-lactone acylase QuiP	-
F9C43_RS21535	4625472..4626833	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
F9C43_RS21540	4627601..4628356	-	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
F9C43_RS21545	4628490..4628858	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
F9C43_RS21550	4628931..4630217	-	1287	WP_165567180.1	FAD-binding oxidoreductase	-
F9C43_RS21555	4630273..4631862	-	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
F9C43_RS21560	4631941..4632417	+	477	WP_003140638.1	hypothetical protein	-
F9C43_RS34155	4632420..4632695	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T141088 WP_003449003.1 NZ_CP045002:c4628356-4627601 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T141088 NZ_CP059764:464232-464573 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATACGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT141088 WP_003086329.1 NZ_CP045002:c4628858-4628490 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT141088 NZ_CP059764:464002-464232 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Structures

Antitoxin

• AlphaFold DB: V6AJU7