Detailed information of TA system TA141087

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3707272..3708493
• Replicon: chromosome
• Accession: NZ_CP045002
• Organism: Pseudomonas aeruginosa strain PAG5

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: F9C43_RS17230
• Protein ID: WP_003102740.1
• Coordinates: 3707915..3708493 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: F9C43_RS17225
• Protein ID: WP_003088112.1
• Coordinates: 3707272..3707826 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9C43_RS17200	3702840..3703391	+	552	WP_003450159.1	XRE family transcriptional regulator	-
F9C43_RS17205	3703388..3703786	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
F9C43_RS17210	3703799..3704122	-	324	WP_003102734.1	multidrug efflux SMR transporter	-
F9C43_RS17215	3704453..3704914	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
F9C43_RS17220	3704919..3707114	+	2196	WP_014603034.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
F9C43_RS17225	3707272..3707826	+	555	WP_003088112.1	helix-turn-helix domain-containing protein	Antitoxin
F9C43_RS17230	3707915..3708493	+	579	WP_003102740.1	HD domain-containing protein	Toxin
F9C43_RS17235	3708602..3709789	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
F9C43_RS17240	3709779..3711950	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
F9C43_RS17245	3711940..3713217	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T141087 WP_003102740.1 NZ_CP045002:3707915-3708493 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T141087 NZ_CP059764:190382-190648 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT141087 WP_003088112.1 NZ_CP045002:3707272-3707826 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT141087 NZ_CP059764:190119-190382 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07