Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 150152..150657 Replicon chromosome
Accession NZ_CP045002
Organism Pseudomonas aeruginosa strain PAG5

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag F9C43_RS00710 Protein ID WP_003083773.1
Coordinates 150152..150433 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag F9C43_RS00715 Protein ID WP_003112628.1
Coordinates 150430..150657 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9C43_RS00685 145403..146752 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
F9C43_RS00690 146801..147487 + 687 WP_003083762.1 FadR family transcriptional regulator -
F9C43_RS00695 147588..148322 + 735 WP_003117208.1 GntR family transcriptional regulator -
F9C43_RS00700 148526..148912 + 387 WP_014602345.1 aegerolysin family protein -
F9C43_RS00705 148944..149852 - 909 WP_023132709.1 LysR family transcriptional regulator -
F9C43_RS00710 150152..150433 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
F9C43_RS00715 150430..150657 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
F9C43_RS00720 150833..151453 - 621 WP_003101226.1 hypothetical protein -
F9C43_RS00725 151554..152054 + 501 WP_003101228.1 LEA type 2 family protein -
F9C43_RS00730 152127..152468 + 342 WP_034003659.1 alkylphosphonate utilization protein -
F9C43_RS00735 152550..153977 - 1428 WP_003083784.1 GABA permease -
F9C43_RS00740 154146..155639 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T141085 WP_003083773.1 NZ_CP045002:c150433-150152 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T141085 NZ_CP059756:c233350-233078 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT141085 WP_003112628.1 NZ_CP045002:c150657-150430 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT141085 NZ_CP059756:c233613-233350 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References