Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2888153..2888815 Replicon chromosome
Accession NZ_CP044990
Organism Deinococcus sp. AJ005

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DAAJ005_RS15835 Protein ID WP_151847948.1
Coordinates 2888153..2888563 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DAAJ005_RS15840 Protein ID WP_151847949.1
Coordinates 2888567..2888815 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DAAJ005_RS15815 2884279..2885934 - 1656 WP_151847944.1 site-specific DNA-methyltransferase -
DAAJ005_RS15820 2885931..2887265 - 1335 WP_151847945.1 hypothetical protein -
DAAJ005_RS15825 2887412..2887825 - 414 WP_151847946.1 PIN domain-containing protein -
DAAJ005_RS15830 2887822..2888019 - 198 WP_151847947.1 hypothetical protein -
DAAJ005_RS15835 2888153..2888563 - 411 WP_151847948.1 type II toxin-antitoxin system VapC family toxin Toxin
DAAJ005_RS15840 2888567..2888815 - 249 WP_151847949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DAAJ005_RS15845 2889217..2889771 + 555 WP_151847950.1 DUF1440 domain-containing protein -
DAAJ005_RS15850 2889768..2891345 - 1578 WP_151847951.1 NFACT family protein -
DAAJ005_RS15855 2891469..2892416 + 948 WP_151847952.1 RluA family pseudouridine synthase -
DAAJ005_RS15860 2892371..2893108 - 738 WP_151847953.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-126)

Antitoxin

SpoVT-AbrB domain

(14-61)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14826.99 Da        Isoelectric Point: 5.5687

>T141084 WP_151847948.1 NZ_CP044990:c2888563-2888153 [Deinococcus sp. AJ005]
MSSPTHFLDTNTCIYIINKKPPQVAEVFGRHQIGDVALSSVTVAELAFGAAKSVRKGTRETLEEFLLDLMILPFDEAAAW
MYGDLRARLQATGQTIGPLDLQIAAHALSAGVTLVTHNTGEFARVSGLKLENWFPE

Download         Length: 411 bp

>T141084 NZ_CP059756:51071-51328 [Enterococcus faecium]
ATGATTAAGGCTTGGTCTGATGATGCTTGGGATGATTATCTTTATTGGCATGAGCAAGGAAACAAAAGCAATATAAAAAA
GATTAACAAGTTAATAAAAGATATCGATCGTTCCCCCTTTGCTGGATTAGGAAAACCTGAGCCATTAAAGCATGATTTAT
CTGGAAAATGGTCCAGAAGAATTACAGATGAACATAGACTGATATATAGAGTTGAAAATGAAACGATATTTATTTATTCT
GCAAAAGATCACTATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9686.05 Da        Isoelectric Point: 9.8605

>AT141084 WP_151847949.1 NZ_CP044990:c2888815-2888567 [Deinococcus sp. AJ005]
MTKHPATTKTAKLFQTGRSQAVRLPKEYRFEGDEVIIKRVGDGVLLLPRNNRWKNLLSAVERFDVQLEREQPEMQERDWG
EF

Download         Length: 249 bp

>AT141084 NZ_CP059756:50809-51078 [Enterococcus faecium]
ATGGAAGCAGTAGCTTATTCAAATTTCCGCCAAAATTTACGTAGTTATATGAAACAAGTTAATGAGGATGCTGAAACACT
TATTGTAACAAGTAAAGATGTAGAAGATACAGTTGTTGTATTATCAAAAAGAGATTATGATTCTATGCAAGAAACGTTGA
GAACACTTTCTAATAATTACGTCATGGAAAAAATTCGTCGAGGAGATGAACAATTCTCCAAAGGTGCATTTAAAACACAT
GACTTAATCGAGGTTGAATCTGATGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References