Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 78211..78742 Replicon plasmid pPBL-H3_B2-2
Accession NZ_CP044977
Organism Hydrogenophaga sp. PBL-H3 substr. PBL-H3(B2)

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag F9Z45_RS22570 Protein ID WP_011114071.1
Coordinates 78461..78742 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag F9Z45_RS22565 Protein ID WP_011114070.1
Coordinates 78211..78474 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9Z45_RS22520 73417..74181 - 765 WP_011114061.1 ParA family protein -
F9Z45_RS22525 74178..74486 - 309 WP_011114062.1 KorA protein -
F9Z45_RS22530 74593..74922 - 330 WP_011114064.1 DUF2761 domain-containing protein -
F9Z45_RS22535 74924..75250 - 327 WP_011114065.1 hypothetical protein -
F9Z45_RS22540 75459..75695 - 237 WP_011114066.1 stable inheritance protein KleA -
F9Z45_RS22545 75853..76110 - 258 WP_011114067.1 hypothetical protein -
F9Z45_RS22550 76127..77335 - 1209 WP_011114068.1 hypothetical protein -
F9Z45_RS22555 77347..77610 - 264 WP_011296181.1 hypothetical protein -
F9Z45_RS22560 77610..78038 - 429 WP_011114069.1 antirestriction protein -
F9Z45_RS22565 78211..78474 + 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F9Z45_RS22570 78461..78742 + 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
F9Z45_RS22575 79459..82374 + 2916 WP_003158660.1 Tn3-like element IS1071 family transposase -
F9Z45_RS22580 82491..82727 - 237 WP_159597444.1 hypothetical protein -
F9Z45_RS22585 82741..83397 - 657 WP_159609100.1 OmpA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - virB11 / virB4 1..107359 107359
- flank IS/Tn - - 79459..82374 2915


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T141080 WP_011114071.1 NZ_CP044977:78461-78742 [Hydrogenophaga sp. PBL-H3]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T141080 NZ_CP044977:78461-78742 [Hydrogenophaga sp. PBL-H3]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAAGGGCAGCACCGGGCCACGCTCGA
CGCCGACCTGGTGCCCGTCCTGGTCGCGCTCGCCGACGACCAGCCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAGGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCCTCGGCTCTCACTCCGAACTCGGCTTGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT141080 WP_011114070.1 NZ_CP044977:78211-78474 [Hydrogenophaga sp. PBL-H3]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT141080 NZ_CP044977:78211-78474 [Hydrogenophaga sp. PBL-H3]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCCTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTGGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTCAACGATCTGATG
GCCGATCTGCATGCGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References