Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 907981..908483 Replicon chromosome
Accession NZ_CP044975
Organism Hydrogenophaga sp. PBL-H3 substr. PBL-H3(B2)

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag F9Z45_RS04375 Protein ID WP_159603920.1
Coordinates 907981..908235 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag F9Z45_RS04380 Protein ID WP_159603922.1
Coordinates 908232..908483 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9Z45_RS04345 903240..903812 - 573 WP_159608575.1 sigma-70 family RNA polymerase sigma factor -
F9Z45_RS04350 903881..904510 - 630 WP_159608576.1 plastocyanin -
F9Z45_RS04355 904561..905043 - 483 WP_159603912.1 group 1 truncated hemoglobin -
F9Z45_RS04360 905067..906014 - 948 WP_159603914.1 DUF3034 family protein -
F9Z45_RS04365 906241..906840 + 600 WP_159603916.1 ferritin-like domain-containing protein -
F9Z45_RS04370 906886..907947 - 1062 WP_159603918.1 histone deacetylase family protein -
F9Z45_RS04375 907981..908235 - 255 WP_159603920.1 Txe/YoeB family addiction module toxin Toxin
F9Z45_RS04380 908232..908483 - 252 WP_159603922.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
F9Z45_RS04385 908567..908974 + 408 WP_159603924.1 DNA-binding protein -
F9Z45_RS04390 908971..909456 + 486 WP_159603926.1 GNAT family N-acetyltransferase -
F9Z45_RS04395 909362..909904 + 543 WP_159603928.1 isochorismatase family protein -
F9Z45_RS04400 909914..910756 - 843 WP_159603930.1 enoyl-CoA hydratase/isomerase family protein -
F9Z45_RS04405 910716..912023 - 1308 WP_159603932.1 DNA polymerase IV -
F9Z45_RS04410 912088..912813 + 726 WP_159603934.1 SIMPL domain-containing protein -
F9Z45_RS04415 912821..913333 - 513 WP_159603936.1 anti-sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10006.53 Da        Isoelectric Point: 9.6957

>T141078 WP_159603920.1 NZ_CP044975:c908235-907981 [Hydrogenophaga sp. PBL-H3]
VKLVFADEAWEDYVYWQKQDRKMVDRINKLIAEVKRDPFAGVGKPEPLKHALSGFWSRRINDEHRMVYKVEGGSLLIAQL
RYHY

Download         Length: 255 bp

>T141078 NZ_CP059748:c215168-214896 [Enterococcus faecium]
ATGAATAACTATTCTGTGATGATTAAAAACTCGGCTAAAGCTGATTTAAAGAAAATCAAACAGTCTAATTTGAAACCTCA
ATTTGAGAAGGTTATTCAGACTTTAAAGGAAGATCCCTATCTCCCTACCCAATCATTTGAGAAGTTAAAACCTACACATG
AAGGTAGGTATTCTAGAAGATTGAATAGACAACACCGGGTTGTTTATAAGGTAGATGAAGATGAACACGTGGTTGAAATT
TATTCAGCAAGGACGCATTACGAGTCACAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9135.42 Da        Isoelectric Point: 6.9761

>AT141078 WP_159603922.1 NZ_CP044975:c908483-908232 [Hydrogenophaga sp. PBL-H3]
MDAITYSSARANLARTMDRVCNDHEALIITRNGEQSVVMLSLEDYQALEETAYLLRNPTNAKRLLSAVAQLSAGKGVERK
LAP

Download         Length: 252 bp

>AT141078 NZ_CP059748:c215431-215168 [Enterococcus faecium]
ATGGCAAAAACAGTCTTAAATCCTAGCTCAGCACGGAAAAATTTTTATAAGTTGTTGAAAGATGTAAATGAGAATCATAC
GGAAATTGAAATCATTAGTGAGCGCAGTGAAAATAATGCGGTGCTTATTGGTTTGGATGATTGGAAAGCAATCAAAGAAA
CGCTATTACTTGAGCAAATAGGCACTTTGGGTGTTGTTCGTAAGCGAGAAAAAGATGATAGTGGATTTACTAATGTTGAT
GAAATTGATTGGGATAACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References