Detailed information of TA system TA141075

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 907981..908483
• Replicon: chromosome
• Accession: NZ_CP044972
• Organism: Hydrogenophaga sp. PBL-H3 substr. PBL-H3(B4)

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: F9Z44_RS04380
• Protein ID: WP_159603920.1
• Coordinates: 907981..908235 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F9Z44_RS04385
• Protein ID: WP_159603922.1
• Coordinates: 908232..908483 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9Z44_RS04350	903240..903812	-	573	WP_159608575.1	sigma-70 family RNA polymerase sigma factor	-
F9Z44_RS04355	903881..904510	-	630	WP_159608576.1	plastocyanin	-
F9Z44_RS04360	904561..905043	-	483	WP_159603912.1	group 1 truncated hemoglobin	-
F9Z44_RS04365	905067..906014	-	948	WP_159603914.1	DUF3034 family protein	-
F9Z44_RS04370	906241..906840	+	600	WP_159603916.1	ferritin-like domain-containing protein	-
F9Z44_RS04375	906886..907947	-	1062	WP_159603918.1	histone deacetylase family protein	-
F9Z44_RS04380	907981..908235	-	255	WP_159603920.1	Txe/YoeB family addiction module toxin	Toxin
F9Z44_RS04385	908232..908483	-	252	WP_159603922.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
F9Z44_RS04390	908567..908974	+	408	WP_159603924.1	DNA-binding protein	-
F9Z44_RS04395	908971..909456	+	486	WP_159603926.1	GNAT family N-acetyltransferase	-
F9Z44_RS04400	909362..909904	+	543	WP_159603928.1	isochorismatase family protein	-
F9Z44_RS04405	909914..910756	-	843	WP_159603930.1	enoyl-CoA hydratase/isomerase family protein	-
F9Z44_RS04410	910716..912023	-	1308	WP_159603932.1	DNA polymerase IV	-
F9Z44_RS04415	912088..912813	+	726	WP_159603934.1	SIMPL domain-containing protein	-
F9Z44_RS04420	912821..913333	-	513	WP_159603936.1	anti-sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10006.53 Da
• Isoelectric Point: 9.6957

>T141075 WP_159603920.1 NZ_CP044972:c908235-907981 [Hydrogenophaga sp. PBL-H3]
VKLVFADEAWEDYVYWQKQDRKMVDRINKLIAEVKRDPFAGVGKPEPLKHALSGFWSRRINDEHRMVYKVEGGSLLIAQL
RYHY

Nucleotide

• Length: 255 bp

>T141075 NZ_CP059747:186564-186830 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9135.42 Da
• Isoelectric Point: 6.9761

>AT141075 WP_159603922.1 NZ_CP044972:c908483-908232 [Hydrogenophaga sp. PBL-H3]
MDAITYSSARANLARTMDRVCNDHEALIITRNGEQSVVMLSLEDYQALEETAYLLRNPTNAKRLLSAVAQLSAGKGVERK
LAP

Nucleotide

• Length: 252 bp

>AT141075 NZ_CP059747:186301-186564 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA