Detailed information of TA system TA141074

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 489835..490409
• Replicon: chromosome
• Accession: NZ_CP044971
• Organism: Brucella anthropi strain T16R-87

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FT787_RS15060
• Protein ID: WP_010660356.1
• Coordinates: 489835..490212 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A849KU45
• Locus tag: FT787_RS15065
• Protein ID: WP_010660355.1
• Coordinates: 490209..490409 (-)
• Length: 67 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FT787_RS15040	485163..486047	+	885	WP_151612517.1	polysaccharide deacetylase	-
FT787_RS15045	486058..487422	+	1365	WP_151612780.1	MmgE/PrpD family protein	-
FT787_RS15050	487485..488645	+	1161	WP_029928473.1	PLP-dependent aminotransferase family protein	-
FT787_RS15055	488754..489644	+	891	WP_151612519.1	DMT family transporter	-
FT787_RS15060	489835..490212	-	378	WP_010660356.1	type II toxin-antitoxin system VapC family toxin	Toxin
FT787_RS15065	490209..490409	-	201	WP_010660355.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
FT787_RS15070	490620..493154	-	2535	WP_010660341.1	GAF domain-containing protein	-
FT787_RS15075	493417..494145	+	729	WP_010660340.1	Crp/Fnr family transcriptional regulator	-
FT787_RS15080	494196..494789	+	594	WP_010660339.1	biliverdin-producing heme oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-110)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 13961.17 Da
• Isoelectric Point: 7.0615

>T141074 WP_010660356.1 NZ_CP044971:c490212-489835 [Brucella anthropi]
VILADTSIWIDHFRRGDNDLVKIIGNDLLLCHPAVIGELALGSLRDRTAVLTFLRAQRETIVATHDEVMTLIERHSVFSM
GIGYTDAHLLASVLLDQRTSLWTRDKRLKLAALKAGAALYEPFHS

Nucleotide

• Length: 378 bp

>T141074 NZ_CP059743:17671-18534 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGTATTTAA

Antitoxin

Protein

• Length: 67 a.a.
• Molecular weight: 7162.26 Da
• Isoelectric Point: 11.1107

>AT141074 WP_010660355.1 NZ_CP044971:c490409-490209 [Brucella anthropi]
MRSTINLDDNLLEKARSLTGTKETAALVRQALEALVRVETGKRLIALGGTMPDAEAAPRRRSSVNK

Nucleotide

• Length: 201 bp

>AT141074 NZ_CP059743:17397-17669 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Structures

Antitoxin

• AlphaFold DB: A0A849KU45