Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 460824..461455 Replicon chromosome
Accession NZ_CP044971
Organism Brucella anthropi strain T16R-87

Toxin (Protein)


Gene name vapC Uniprot ID A0A256GHB5
Locus tag FT787_RS14930 Protein ID WP_029928525.1
Coordinates 461054..461455 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A256GGW7
Locus tag FT787_RS14925 Protein ID WP_010660354.1
Coordinates 460824..461054 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FT787_RS14910 457607..458470 - 864 WP_151895749.1 class I SAM-dependent methyltransferase -
FT787_RS14915 458467..459153 - 687 WP_151895750.1 TetR/AcrR family transcriptional regulator -
FT787_RS14920 459359..460252 + 894 WP_151895751.1 NAD(P)/FAD-dependent oxidoreductase -
FT787_RS14925 460824..461054 + 231 WP_010660354.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FT787_RS14930 461054..461455 + 402 WP_029928525.1 tRNA(fMet)-specific endonuclease VapC Toxin
FT787_RS14935 462142..463302 + 1161 WP_029928521.1 mandelate racemase/muconate lactonizing enzyme family protein -
FT787_RS14940 463463..464368 + 906 WP_094515270.1 LysR family transcriptional regulator -
FT787_RS14945 464498..466018 + 1521 WP_029928517.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15055.14 Da        Isoelectric Point: 6.8629

>T141073 WP_029928525.1 NZ_CP044971:461054-461455 [Brucella anthropi]
MLKYMLDTNICIFTIKNRPQQVREAFNRFHDQLCISSVSLMELIYGAEKSAHPEKNLAVVEGFAARLEVLSYDEPAANHT
GQLRAELARSGTPIGPYDQLIAGHARSRGLIIVTNNRREFDRVPGLRVEDWTD

Download         Length: 402 bp

>T141073 NZ_CP059742:22964-23314 [Enterococcus faecium]
ATGGTGAGAAAACCTAGACAAGGCGATATTCTATTATTGAATACAGCACCTCGATCTGGACACGAACAGACAGGTAAAAG
ACCTTATATTGTTTTAAGTCATGATATTATTGCGGATTATAGTAACGTTGTTACAGTTGCTCCAATTTCTAGTACAACTA
GAAACTATCCGCTATATGTAAATATAAACTCAGAATATGAAATGAAGACAACAGGAAAAGTATTATTAGATCAACTAACG
ACAATTGATTATGAAGCCAGAGAGTGTATTTTTTTGGAAAAAGCGCATGATAGTTTAGTTGAGGAGTTATTGATGAAAGT
TAGAACAGTTTTTCAAAAAGTAAGCAAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8487.53 Da        Isoelectric Point: 4.5045

>AT141073 WP_010660354.1 NZ_CP044971:460824-461054 [Brucella anthropi]
MEQGAVFQSNRSQAIRLPKAVALPADVKRVDIVAVGRTRIIAPAGEVWDSWFDSLEATSDFMNERDQPAPQEREAF

Download         Length: 231 bp

>AT141073 NZ_CP059742:22707-22970 [Enterococcus faecium]
ATGGAAATGTTACCTATAAAAAAATGGGGAAATAGTAATGGCCTTAGATTGCCAAAGTATATTATGGAATATCTTGGAAT
TCATACAGAAGACAAAGTGAAGATAATACAAGAAGAAGTAAACGGTCAGAAGCGGCTAATTATCGAAGCGGCTAATATAG
AAAATGAATTAACAATTGAACAGTTATTTGAAAATTACACTGATGAAAGAAATCATGTGACGATTCAAAATTTAGGTGAA
GCAGTAGGTAATGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A256GHB5

Antitoxin

Source ID Structure
AlphaFold DB A0A256GGW7

References