Detailed information of TA system TA141069

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 824..1296
• Replicon: plasmid PNCS007087 strain 14[5]12:i:-
• Accession: NZ_CP044960
• Organism: Salmonella enterica subsp. enterica serovar 14[5]12:i:- strain PNCS007087

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: E5O00_RS25410
• Protein ID: WP_151884631.1
• Coordinates: 824..1030 (-)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: E0WH52
• Locus tag: E5O00_RS25415
• Protein ID: WP_000079932.1
• Coordinates: 1027..1296 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
E5O00_RS26160	1..780	+	780	WP_001323403.1	IS21-like element IS100kyp family helper ATPase IstB	-
E5O00_RS25410	824..1030	-	207	WP_151884631.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
E5O00_RS25415	1027..1296	-	270	WP_000079932.1	hypothetical protein	Antitoxin
E5O00_RS25430	2204..3235	-	1032	WP_001690254.1	replication initiation protein	-
E5O00_RS25445	4208..4471	+	264	WP_001324596.1	ash family protein	-
E5O00_RS25450	4389..4676	+	288	WP_000074849.1	conjugal transfer protein TraA	-
E5O00_RS25460	5118..5651	+	534	WP_001372168.1	transcription termination factor NusG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..91139	91139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (22-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (5-69)

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 10173.20 Da
• Isoelectric Point: 5.5500

>T141069 WP_151884631.1 NZ_CP044960:c1030-824 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 207 bp

>T141069 NZ_CP059739:188086-188352 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 13263.91 Da
• Isoelectric Point: 5.5500

>AT141069 WP_000079932.1 NZ_CP044960:c1296-1027 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Nucleotide

• Length: 270 bp

>AT141069 NZ_CP059739:187823-188086 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A5U8RN22