Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 62908..63439 Replicon plasmid pBPS33-2
Accession NZ_CP044551
Organism Hydrogenophaga sp. BPS33

Toxin (Protein)


Gene name relE Uniprot ID I2ALI9
Locus tag F9K07_RS31305 Protein ID WP_011114071.1
Coordinates 63158..63439 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID I2ALI8
Locus tag F9K07_RS31300 Protein ID WP_011114070.1
Coordinates 62908..63171 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F9K07_RS31255 58114..58878 - 765 WP_011114061.1 ParA family protein -
F9K07_RS31260 58875..59183 - 309 WP_011114062.1 KorA protein -
F9K07_RS31265 59290..59619 - 330 WP_011114064.1 DUF2761 domain-containing protein -
F9K07_RS31270 59621..59947 - 327 WP_011114065.1 hypothetical protein -
F9K07_RS31275 60156..60392 - 237 WP_011114066.1 stable inheritance protein KleA -
F9K07_RS31280 60550..60807 - 258 WP_011114067.1 hypothetical protein -
F9K07_RS31285 60824..62032 - 1209 WP_011114068.1 hypothetical protein -
F9K07_RS31290 62044..62307 - 264 WP_011296181.1 hypothetical protein -
F9K07_RS31295 62307..62735 - 429 WP_011114069.1 antirestriction protein -
F9K07_RS31300 62908..63171 + 264 WP_011114070.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F9K07_RS31305 63158..63439 + 282 WP_011114071.1 type II toxin-antitoxin system YafQ family toxin Toxin
F9K07_RS31310 64156..67071 + 2916 WP_003049965.1 Tn3-like element IS1071 family transposase -
F9K07_RS31315 67317..67943 - 627 WP_068683781.1 lytic transglycosylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - virB11 / virB4 1..106879 106879
- flank IS/Tn - - 64156..67071 2915


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-83)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10743.19 Da        Isoelectric Point: 7.4750

>T141067 WP_011114071.1 NZ_CP044551:63158-63439 [Hydrogenophaga sp. BPS33]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALADDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRLGSHSELGL

Download         Length: 282 bp

>T141067 NZ_CP059738:c5834659-5834315 [Pseudomonas sp. 29A]
ATGCGAACCGTATTCTTTGAAACAACGATATTTACCACAAGCGTTGGTCAGTACCTGACAGACGATGAGTACCGAGAACT
GCAGGCTTATATGCAGGGCAATCCGTTGGCAGGCGATGTGATGCCCCGAACGGGTGGATTCAGAAAACTACGTTGGGCTG
ATGCTCGACGTGGCAAGGGCCGACGAGGCGGCTTGCGGGTCATCTATTATTGGCTTATGAATGATGGTCAGTTCTGGATG
TTTGCAATTTACGACAAAGATGAGCTTGATAATCTGACTGCCGAGCAAGAAAAGGCGCTCAAAAAAGCCATAGATAAAGA
GTTGAAAACACGAGGTACCCCATGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9255.82 Da        Isoelectric Point: 5.7905

>AT141067 WP_011114070.1 NZ_CP044551:62908-63171 [Hydrogenophaga sp. BPS33]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVNDLM
ADLHAAD

Download         Length: 264 bp

>AT141067 NZ_CP059738:c5834318-5834004 [Pseudomonas sp. 29A]
ATGAAAAAACGCGACCTGTTTGCAGAGTTGATGCAGGGCGTTGATGAGATGGCGGCTCAACGCGAAGGAAAAATTACCCT
GCGCAATACAGTGCTTGAGGACAAACCAGTCCCGGAAGTCGGAGCCCAAGAAATCGTGGCTTTGAGAGAAAGGTTACATA
TGTCTCAAGCCGTCTTTGCCAAACGAATCAGGGCGAGTCCCAGCACTCTGAGAAACTGGGAGCAGGAAAAGTCAAAGCCA
AATGCTCAAGCTGCTTTGTTGATCCGTTTGGTTGAAAAATTCCCTGACATGGTTGACCGCCTGAGCGCCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9V4I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1U9V3I2

References