Detailed information of TA system TA141065

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 3148098..3148672
• Replicon: chromosome
• Accession: NZ_CP044549
• Organism: Hydrogenophaga sp. BPS33

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F9K07_RS14505
• Protein ID: WP_159594105.1
• Coordinates: 3148301..3148672 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: F9K07_RS14500
• Protein ID: WP_159594104.1
• Coordinates: 3148098..3148304 (+)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F9K07_RS14485	3143337..3144209	-	873	WP_159594102.1	TauD/TfdA family dioxygenase	-
F9K07_RS14490	3144316..3146976	-	2661	WP_159596940.1	[protein-PII] uridylyltransferase	-
F9K07_RS14495	3147011..3147841	-	831	WP_159594103.1	type I methionyl aminopeptidase	-
F9K07_RS14500	3148098..3148304	+	207	WP_159594104.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
F9K07_RS14505	3148301..3148672	+	372	WP_159594105.1	type II toxin-antitoxin system VapC family toxin	Toxin
F9K07_RS14510	3148767..3152780	+	4014	WP_159594106.1	phosphoribosylformylglycinamidine synthase	-
F9K07_RS14515	3152971..3153246	+	276	WP_159594107.1	DUF2164 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-108)

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-42)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 13357.41 Da
• Isoelectric Point: 7.1864

>T141065 WP_159594105.1 NZ_CP044549:3148301-3148672 [Hydrogenophaga sp. BPS33]
MILVDTSVWIDHLRSSDAALVERLHQGAVLGHPFVTGELALGSLRQRAAVLEALRALPQATPARDDEVLLFVEQHALHGL
GIGWVDAHLLAATRLTAGAQLWTRDKRLLATCQRLGLAHQAAH

Nucleotide

• Length: 372 bp

>T141065 NZ_CP059738:2166464-2166676 [Pseudomonas sp. 29A]
GTGCAAAGCAGGCAATTGATCAAGGAGCTGGAGGAGGCTGGCTGGGTGCTGGATCGGGTCACTGGCAGTCATCACATCTT
CAGGCACCGATACAACCCGTACACGATTCCCGTTCCTCACCCGAAAAAGGATTTGCCACTGGGGACGGTCAAAAGCATCA
GGAGGCGTGCCGGGTTGTACAACCCGCCAGCCAGTTATGAAGGAGATCCGTAA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7600.74 Da
• Isoelectric Point: 8.9754

>AT141065 WP_159594104.1 NZ_CP044549:3148098-3148304 [Hydrogenophaga sp. BPS33]
MRTTLALDDDLLAQAQQMTGLVEKSTLVREALRALIQRESAKRLALLGGTEPDLVDVPRRREGRAERT

Nucleotide

• Length: 207 bp

>AT141065 NZ_CP059738:2166676-2167080 [Pseudomonas sp. 29A]
ATGCAATATCCAATCTGCATCGAATGGGGTGATGAAAATACCGCCATCGGTATTCAGATCCCCGATATTCCCGGCGCCGT
TACAGCAGGGGATAGCTTTGAAGATGCCTACAAGGCGGCGGTTGAAGTCGCCCACATCATGCTGCAGGAGATTGCGGCGG
ACGGGGAGTCGATTCCTATGCCGACTTCGGCATCCGCTCATCGCAGTAATCCGGACTTTGCCAATATGGGATGGGGCATG
CTCGAGCTGGACATTTCGCCCTATCTCGGCAAGACCGAGAAGGTCAACGTAACGCTGCCCGGTTACGTGATTCAGCGAAT
CGATCGTTATGTGCGCGAACACAATGTCAAAAGCCGCTCCTCCTTTCTGGCGGATGCGGCGATGGAGAAACTGGTTCGTT
ATTAA