Detailed information of TA system TA141063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 5641050..5641608
• Replicon: chromosome
• Accession: NZ_CP044546
• Organism: Pseudomonas sp. CFA

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: F7661_RS25265
• Protein ID: WP_064492301.1
• Coordinates: 5641050..5641379 (-)
• Length: 110 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: F7661_RS25270
• Protein ID: WP_064492302.1
• Coordinates: 5641369..5641608 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7661_RS25235	5636085..5636438	+	354	WP_064491737.1	hypothetical protein	-
F7661_RS25240	5636719..5637924	+	1206	WP_104960601.1	ISL3 family transposase	-
F7661_RS25245	5638175..5638711	+	537	WP_104886581.1	Bro-N domain-containing protein	-
F7661_RS25250	5639052..5639315	+	264	WP_021784483.1	hypothetical protein	-
F7661_RS25255	5639302..5640035	+	734	Protein_4952	zeta toxin family protein	-
F7661_RS25260	5640284..5640790	+	507	Protein_4953	Bro-N domain-containing protein	-
F7661_RS25265	5641050..5641379	-	330	WP_064492301.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F7661_RS25270	5641369..5641608	-	240	WP_064492302.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
F7661_RS25275	5642426..5643664	+	1239	WP_104960953.1	OprD family porin	-
F7661_RS25280	5644200..5645006	+	807	WP_190869639.1	NAD(P)-dependent oxidoreductase	-
F7661_RS25285	5645029..5645910	+	882	WP_190869640.1	SMP-30/gluconolactonase/LRE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-76)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-70)

Sequences

Toxin

Protein

• Length: 110 a.a.
• Molecular weight: 12987.13 Da
• Isoelectric Point: 10.5350

>T141063 WP_064492301.1 NZ_CP044546:c5641379-5641050 [Pseudomonas sp. CFA]
MTYSLDFDARALKEWKKLGDTVRQQFKKKLAEVLLKSRIEANRLHSLPDCYKIKLRSSGYRLVYQVIDQEIVVLVVAVDR
RERDQAHKKAAERLEWAYRVWQPQAKISR

Nucleotide

• Length: 330 bp

>T141063 NZ_CP059738:c1842391-1842212 [Pseudomonas sp. 29A]
GTGAATAGCCGTTTTTTAATCGGCCAACTCGTCGCAGACGGTTGGTATCTGGTACGGATCAAAGGAAGTCACCATCACTT
CAAGCATCCGAGCAAACCAGGACTGGTCACCGTGCCACATCCGAAAAAGGATCTGCTGAAGAAAACGGCCATCAGTATTT
TGCAGCAGGCGCTGCTTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9097.44 Da
• Isoelectric Point: 4.6310

>AT141063 WP_064492302.1 NZ_CP044546:c5641608-5641369 [Pseudomonas sp. CFA]
MASINIRVDDDLKARAYKELERLGVTPSELMRQALQYVAERGKLPFRPVLMTEEDEDLIATVQERLGSPQRVRVQLDDL

Nucleotide

• Length: 240 bp

>AT141063 NZ_CP059738:c1842175-1841768 [Pseudomonas sp. 29A]
ATGCTCTACCCGATTGCGATTTCAATTGGCGATGACCATCACGCCTGGGGTGTAGAAGTCCCGGACATTCCTGGATGCTT
TTCCGCCGGAGAGGATCTGGACGATGCCGTCGCCATGGCTCGCGAAGCCATCGAAGGTCATTTCGAGATTCTCGCGGACG
ACGACGCCCCCATTCCAGCGGCCAGCAAACTGAGCCTGCACGTAGCCAACCCGAAATACGCCGGTTGTGCATGGGCCGTG
GTGGATATCGATGTGCTCAAGTATTTGGGCAAAGCCCAAAAGCTCAACATCACCCTGCCTGGGCACTTGCTCAACCGCAT
TGATGAATATGTGTTGCATCACCCGGAAGAGAAAAGCCGTTCCGGGTTTCTGGCTTCGGCAGCGTTGAAGGTATTGCAGC
AGGGTTGA