Detailed information of TA system TA141057

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yafQ-relB/YafQ-DinJ
• Location: 898914..899451
• Replicon: chromosome
• Accession: NZ_CP044534
• Organism: Limosilactobacillus frumenti strain LF145

Toxin (Protein)

• Gene name: yafQ
• Uniprot ID: -
• Locus tag: LF145_RS04380
• Protein ID: WP_057750814.1
• Coordinates: 898914..899213 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LF145_RS04385
• Protein ID: WP_057750816.1
• Coordinates: 899203..899451 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LF145_RS04355	893926..894750	-	825	WP_057750799.1	glycosyltransferase family 8 protein	-
LF145_RS04360	894812..895465	+	654	WP_057750801.1	HD domain-containing protein	-
LF145_RS04365	895504..896121	-	618	WP_057750804.1	hypothetical protein	-
LF145_RS04370	896118..896996	-	879	WP_057750807.1	DegV family protein	-
LF145_RS04375	897183..898871	+	1689	WP_057750810.1	fibronectin-binding domain-containing protein	-
LF145_RS04380	898914..899213	-	300	WP_057750814.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
LF145_RS04385	899203..899451	-	249	WP_057750816.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LF145_RS04390	899665..902145	-	2481	WP_057750819.1	ATP-grasp domain-containing protein	-
LF145_RS04395	902145..903227	-	1083	WP_057750821.1	carbamoyl phosphate synthase small subunit	-
LF145_RS04400	903262..904176	-	915	WP_057750824.1	RluA family pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-91)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-74)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11982.18 Da
• Isoelectric Point: 10.5425

>T141057 WP_057750814.1 NZ_CP044534:c899213-898914 [Limosilactobacillus frumenti]
MKIEQVPTFKRNVKKLKRKHYDMERLKKVVKLIVENDVEELKRKHKLGIIKGTRPTVWHVHVDRSYNDDWVLCYRIENNR
LVLLLLTTGNHDVLKHIPY

Nucleotide

• Length: 300 bp

>T141057 NZ_CP059733:c4772099-4771797 [Thalassomonas viridans]
ATGAAAGCATTTGTATTGACCAATGCTGCAAAAGCCGATTTGAAAAGGCTCGCATTGTATACCCAAAAGGAATGGGGTAA
AGAACAACGAAATCTTTATCTTAAGCAATTCGATGATGCTTTTTATATGCTTGCCGATACGCCTTCGGTAGGCAAAGCTT
GTGATAATATAAAAGCAGGTTATAAAAAATTCCCTATTGGCAGCCATATAGTTTTTTATAAAAAAGGGGCTGATGCTTAT
ATTGAGGTTATACGTATTCTTCATAAACGTATGGATGCTGAAGTTAATCTGCAAGGTTTATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9254.23 Da
• Isoelectric Point: 3.9837

>AT141057 WP_057750816.1 NZ_CP044534:c899451-899203 [Limosilactobacillus frumenti]
MAQINIKIDDDLKQDATRVFSSMGLDLSTGIKIYLKRVTQDNKLPFTPKATSELDQAIAEADRGQVETFDNFDEWADSLD
ED

Nucleotide

• Length: 249 bp

>AT141057 NZ_CP059733:c4772338-4772102 [Thalassomonas viridans]
ATGGCTAAAAATACAAGCATTACCCTTGGCGAGCATTTTGATGGCTTTATTACTAGCCAGATAAATACGGGCAGATATAA
CTCTGCGAGTGAAGTGATAAGGGCGGGGTTACGCTTACTTGAAAAAAGTGAAACCAAAACTGAAGTTTTGAGACGTATGT
TGGATGAGGGCGAACAAAGCGGTATTGCGGAATACAGTTTTGATGCCCTTATTGAGGAATTGGATGCTGAAAGTTAG