Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5847249..5847859 Replicon chromosome
Accession NZ_CP044527
Organism Klebsiella grimontii strain SS141

Toxin (Protein)


Gene name vapC Uniprot ID A0A9E1GAR7
Locus tag EHW69_RS28410 Protein ID WP_049086919.1
Coordinates 5847249..5847623 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag EHW69_RS28415 Protein ID WP_077253475.1
Coordinates 5847620..5847859 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHW69_RS28395 5844404..5845306 + 903 WP_004122548.1 formate dehydrogenase subunit beta -
EHW69_RS28400 5845303..5845938 + 636 WP_004132860.1 formate dehydrogenase cytochrome b556 subunit -
EHW69_RS28405 5846282..5847211 + 930 WP_004132861.1 formate dehydrogenase accessory protein FdhE -
EHW69_RS28410 5847249..5847623 - 375 WP_049086919.1 type II toxin-antitoxin system VapC family toxin Toxin
EHW69_RS28415 5847620..5847859 - 240 WP_077253475.1 ribbon-helix-helix domain-containing protein Antitoxin
EHW69_RS28420 5848065..5848982 + 918 WP_024360706.1 alpha/beta hydrolase -
EHW69_RS28425 5849000..5849941 - 942 WP_162685383.1 fatty acid biosynthesis protein FabY -
EHW69_RS28430 5849986..5850423 - 438 WP_004132870.1 D-tyrosyl-tRNA(Tyr) deacylase -
EHW69_RS28435 5850420..5851280 - 861 WP_004127107.1 virulence factor BrkB family protein -
EHW69_RS28440 5851274..5851873 - 600 WP_004132872.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14111.45 Da        Isoelectric Point: 8.4571

>T141054 WP_049086919.1 NZ_CP044527:c5847623-5847249 [Klebsiella grimontii]
MIKGPALFDTNILIDLFSGRVEAKQVLEAYPPQNAISLITWMEVMVGAKKYHQEHRTRIALSAFNIIDISQDIAERSVNL
RKEYGMKLPDAIILATAQIHRYELVTRNTKDFFGIPGVITPYHL

Download         Length: 375 bp

>T141054 NZ_CP059733:c1069516-1069217 [Thalassomonas viridans]
ATGGTTGAAATAATATGGACCGAACCTGCATTAAATGATTTAAATGACGTAATAGAATATATCGCTCTGCAAAATGTTAA
AGCCGCAAAAAAACTTACTCAAACTATCTTTAGTAAAATAGAGCGCTTAGCCTTCTTTCCCCACTCAGGAAAAGTCCCCG
AAGAATTAACAATGCTTAACTTTAAAGAAGTCGTCGTTCCTCCATGCCGGATATTTTATAGAGTAGCGGAAGACAAAGTC
TATATTTTGCATGTAATGCGCCAAGAACGGGATTTAGCCCGTTTTCTCCTATCTCACTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9293.49 Da        Isoelectric Point: 4.3142

>AT141054 WP_077253475.1 NZ_CP044527:c5847859-5847620 [Klebsiella grimontii]
MMTGTNMGRILLDLSDDVIKRLEDLKQQRNLPRAELLREAVEQYLERQADTTISNALGIWQGCEEDGVEFERKLREEWQ

Download         Length: 240 bp

>AT141054 NZ_CP059733:c1069761-1069504 [Thalassomonas viridans]
ATGAAAGTAGAATTAGTAACAACACTGAAGCGCCAAGCTACAAAAATTCTTGCAGATTTACATGCCTCCAAAGAACCTGT
ACTTATTACAGAGCATGGTCAGCCTTCGGCCTACCTTGTAGATGTTGATGATTATGAACTGATGAAAAAACGTATGGCTA
TTTTAGAGGGCATAGCCAGAGGAGAAAAAGCTATTTCAGAAGATCGCACGTTTTCCCATGAGCAAGCACAAGAGAAAATG
GCTAAATGGTTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References