Detailed information of TA system TA141053

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 4733355..4734174
• Replicon: chromosome
• Accession: NZ_CP044527
• Organism: Klebsiella grimontii strain SS141

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: A0A9E1D5M6
• Locus tag: EHW69_RS23095
• Protein ID: WP_004132607.1
• Coordinates: 4733917..4734174 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A9E1DGJ5
• Locus tag: EHW69_RS23090
• Protein ID: WP_004132606.1
• Coordinates: 4733355..4733906 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EHW69_RS23075	4728745..4730142	+	1398	WP_004132593.1	MFS transporter	-
EHW69_RS23080	4730266..4731606	+	1341	WP_112070250.1	carbohydrate porin	-
EHW69_RS23085	4731709..4733337	-	1629	WP_049085653.1	SAM-dependent methyltransferase	-
EHW69_RS23090	4733355..4733906	-	552	WP_004132606.1	N-acetyltransferase	Antitoxin
EHW69_RS23095	4733917..4734174	-	258	WP_004132607.1	YjhX family toxin	Toxin
EHW69_RS23100	4734758..4735942	+	1185	WP_049085652.1	mannonate dehydratase	-
EHW69_RS23105	4736019..4737494	+	1476	WP_024359122.1	fructuronate reductase	-
EHW69_RS23110	4737631..4738407	+	777	WP_024359123.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (34-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9538.04 Da
• Isoelectric Point: 11.1381

>T141053 WP_004132607.1 NZ_CP044527:c4734174-4733917 [Klebsiella grimontii]
MNLSRQEQRTLHVLAKGGRIAHVRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T141053 NZ_CP059732:6977871-6978062 [Spirosoma sp. PL0136]
ATTAAGTTTCGTGAGATCGTTCGTCTGATTGAAGAAGATGGATGGTATCAGGTTCGGCAACGAGGTAGCCACCGTCAATT
CAAGCACACTAGTAAAACAGGTTTAGTGACAATAGCGTACCATAGTTTGAATGACTCTGTTCCCTCAGGAACGTTGAGTA
GTATTTATAAACAGGCGCAGATTGAACGATGA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19990.89 Da
• Isoelectric Point: 7.2343

>AT141053 WP_004132606.1 NZ_CP044527:c4733906-4733355 [Klebsiella grimontii]
MTNHSFTFHVASEGDTNDILHVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGKAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGGLIRHGIEQLKAMGSQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEALKACWMLQPLSS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT141053 NZ_CP059732:6978059-6978274 [Spirosoma sp. PL0136]
ATGAAAAAGTATTTGGTCATTATCGAGAAATCCGATACAGGTTACGGTGCTTATGTCCCTGATTTACCGGGGTGTGTAGC
AACCGCACCGACCAAAGATGAAGTCGAGCGTTTGATTTATGAAGGAATCCAATTTCACATTGAAGGTTTAGAATTGGAAG
GTCTGTCTATTCCTGTAGCCAGTTCAGAAGCCGAAACAATGGTTTTTGCAGATTAA