Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4516474..4517093 Replicon chromosome
Accession NZ_CP044527
Organism Klebsiella grimontii strain SS141

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag EHW69_RS22040 Protein ID WP_004099646.1
Coordinates 4516875..4517093 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag EHW69_RS22035 Protein ID WP_004129911.1
Coordinates 4516474..4516848 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHW69_RS22025 4511643..4512836 + 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
EHW69_RS22030 4512859..4516005 + 3147 WP_004848339.1 multidrug efflux RND transporter permease subunit -
EHW69_RS22035 4516474..4516848 + 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
EHW69_RS22040 4516875..4517093 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
EHW69_RS22045 4517255..4517821 + 567 WP_049085237.1 maltose O-acetyltransferase -
EHW69_RS22050 4517948..4518418 + 471 WP_004136048.1 YlaC family protein -
EHW69_RS22055 4518393..4519847 - 1455 WP_049085239.1 PLP-dependent aminotransferase family protein -
EHW69_RS22060 4519948..4520646 + 699 WP_004136044.1 GNAT family N-acetyltransferase -
EHW69_RS22065 4520643..4520783 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
EHW69_RS22070 4520783..4521046 - 264 WP_004129897.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T141052 WP_004099646.1 NZ_CP044527:4516875-4517093 [Klebsiella grimontii]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T141052 NZ_CP059731:c15864-15577 [Acinetobacter baumannii]
ATGGAACAGTATTTTGAATGGGATGAGGCTAAGAATCGAAAGAATCAGAAAAAGCATGATATCTCTTTCGAAACTGCAAG
CCTTGTTTTTGAAGATCCATTACGGATCTCAATCCAAGACAGATATACTAATGGTGAAGAACGTTGGCAAACCATTGGAC
GAGTTAAAGGCGTACTAATGTTATTGGTGGCTCACACCATTTTTGATGAAGATGACTGTGAAATCATCCGAATCATTAGT
GCAAGGCAAGTCACTAAAGCGGAGCGAAACAAATATGAGCATGGTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT141052 WP_004129911.1 NZ_CP044527:4516474-4516848 [Klebsiella grimontii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT141052 NZ_CP059731:c15590-15276 [Acinetobacter baumannii]
ATGAGCATGGTTAGATACTCACACAAAGAGCTGAATGAGAAATTTGGTGAGAAGCAAGATGCTGAAATTCAACGCTTGCT
TGCTAAAGGCACGGTTCCTGATGATCAGCTAGATCTATCAGATATTCCTGAAATTACAGACTGGAGCAATGCTGTACGCC
AAAATCAATTTTACCGCCCAGTAAAGCAACAAACTTCAATTCGGTTAGATGCTGATGTACTTGCTTGGTTCAAAGCACAA
GGCAAAGGTTATCAAACACGTATGAATGAAATTTTACGAGATGCTATGCTAAAAGAATTAAAAAATCATCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References