141042

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 961107..961764 Replicon chromosome
Accession NZ_CP044527
Organism Klebsiella grimontii strain SS141

Toxin (Protein)


Gene name cptA Uniprot ID A0A285B9I7
Locus tag EHW69_RS04785 Protein ID WP_004134421.1
Coordinates 961354..961764 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag EHW69_RS04780 Protein ID WP_004105561.1
Coordinates 961107..961373 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EHW69_RS04755 956286..957719 - 1434 WP_004133593.1 6-phospho-beta-glucosidase -
EHW69_RS04760 957841..958569 - 729 WP_024358621.1 MurR/RpiR family transcriptional regulator -
EHW69_RS04765 958620..958931 + 312 WP_004133599.1 N(4)-acetylcytidine aminohydrolase -
EHW69_RS04770 959094..959753 + 660 WP_004124978.1 hemolysin III family protein -
EHW69_RS04775 959880..960863 - 984 WP_049087337.1 tRNA-modifying protein YgfZ -
EHW69_RS04780 961107..961373 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
EHW69_RS04785 961354..961764 + 411 WP_004134421.1 protein YgfX Toxin
EHW69_RS04790 961773..962294 - 522 WP_004134423.1 flavodoxin FldB -
EHW69_RS04795 962416..963312 + 897 WP_004124942.1 site-specific tyrosine recombinase XerD -
EHW69_RS04800 963335..964048 + 714 WP_004134425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EHW69_RS04805 964054..965787 + 1734 WP_004134426.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16075.86 Da        Isoelectric Point: 10.9455

>T141042 WP_004134421.1 NZ_CP044527:961354-961764 [Klebsiella grimontii]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQE

Download         Length: 411 bp

>T141042 NZ_CP059723:2386612-2387076 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT141042 WP_004105561.1 NZ_CP044527:961107-961373 [Klebsiella grimontii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT141042 NZ_CP059723:2386277-2386612 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A285B9I7

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References