Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 772469..773223 | Replicon | chromosome |
| Accession | NZ_CP044527 | ||
| Organism | Klebsiella grimontii strain SS141 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A6L5EGB6 |
| Locus tag | EHW69_RS03855 | Protein ID | WP_032669201.1 |
| Coordinates | 772846..773223 (+) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | EHW69_RS03850 | Protein ID | WP_074143921.1 |
| Coordinates | 772469..772795 (+) | Length | 109 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| EHW69_RS03805 | 767697..768410 | + | 714 | WP_032669194.1 | WYL domain-containing protein | - |
| EHW69_RS03810 | 768407..769042 | + | 636 | WP_020837117.1 | hypothetical protein | - |
| EHW69_RS03815 | 769081..769536 | + | 456 | WP_000754598.1 | hypothetical protein | - |
| EHW69_RS03820 | 769533..769982 | + | 450 | WP_128804924.1 | hypothetical protein | - |
| EHW69_RS03825 | 770054..770285 | + | 232 | Protein_746 | DUF905 domain-containing protein | - |
| EHW69_RS03830 | 770384..771205 | + | 822 | WP_032669198.1 | DUF945 domain-containing protein | - |
| EHW69_RS03835 | 771236..771679 | + | 444 | WP_032669199.1 | antirestriction protein | - |
| EHW69_RS03840 | 771691..772170 | + | 480 | WP_032669200.1 | DNA repair protein RadC | - |
| EHW69_RS03845 | 772191..772412 | + | 222 | WP_023567997.1 | DUF987 domain-containing protein | - |
| EHW69_RS03850 | 772469..772795 | + | 327 | WP_074143921.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| EHW69_RS03855 | 772846..773223 | + | 378 | WP_032669201.1 | TA system toxin CbtA family protein | Toxin |
| EHW69_RS03860 | 773220..773711 | + | 492 | WP_032672023.1 | hypothetical protein | - |
| EHW69_RS03865 | 773741..773944 | + | 204 | WP_032669203.1 | DUF957 domain-containing protein | - |
| EHW69_RS03870 | 774008..774856 | + | 849 | WP_032669204.1 | DUF4942 domain-containing protein | - |
| EHW69_RS03880 | 775159..775665 | + | 507 | WP_024358695.1 | G/U mismatch-specific DNA glycosylase | - |
| EHW69_RS03885 | 775706..776368 | - | 663 | WP_024358694.1 | TetR/AcrR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 759281..773223 | 13942 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 14157.93 Da Isoelectric Point: 6.2236
>T141041 WP_032669201.1 NZ_CP044527:772846-773223 [Klebsiella grimontii]
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLSSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLSSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP
Download Length: 378 bp
>T141041 NZ_CP059723:c2343730-2343416 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA
Antitoxin
Download Length: 109 a.a. Molecular weight: 11953.71 Da Isoelectric Point: 6.8397
>AT141041 WP_074143921.1 NZ_CP044527:772469-772795 [Klebsiella grimontii]
ITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELNPCHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA
ITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELNPCHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA
Download Length: 327 bp
>AT141041 NZ_CP059723:c2343419-2343003 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|