Detailed information of TA system TA141035

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1363067..1363718
• Replicon: chromosome
• Accession: NZ_CP044519
• Organism: Acinetobacter baumannii strain 29FS20

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A5Q0RPK1
• Locus tag: F7R60_RS06430
• Protein ID: WP_000838147.1
• Coordinates: 1363067..1363249 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A335N5K1
• Locus tag: F7R60_RS06435
• Protein ID: WP_000966690.1
• Coordinates: 1363314..1363718 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7R60_RS06380	1358239..1358619	+	381	WP_000505832.1	hypothetical protein	-
F7R60_RS06385	1358619..1358987	+	369	WP_178943566.1	glutamate 5-kinase	-
F7R60_RS06390	1359026..1359688	+	663	WP_001284678.1	hypothetical protein	-
F7R60_RS06395	1359756..1360169	+	414	WP_000626004.1	hypothetical protein	-
F7R60_RS06400	1360135..1360503	+	369	WP_001983390.1	hypothetical protein	-
F7R60_RS06405	1360460..1360903	+	444	WP_074163943.1	hypothetical protein	-
F7R60_RS06410	1360905..1361117	+	213	WP_001983388.1	hypothetical protein	-
F7R60_RS06415	1361225..1362154	+	930	WP_000094301.1	hypothetical protein	-
F7R60_RS06420	1362202..1362735	+	534	WP_001185621.1	hypothetical protein	-
F7R60_RS06425	1362738..1362998	+	261	WP_074163942.1	hypothetical protein	-
F7R60_RS06430	1363067..1363249	+	183	WP_000838147.1	type II toxin-antitoxin system HicA family toxin	Toxin
F7R60_RS06435	1363314..1363718	+	405	WP_000966690.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
F7R60_RS06440	1363817..1363993	+	177	WP_001983384.1	hypothetical protein	-
F7R60_RS06445	1364002..1364325	+	324	WP_000523922.1	DUF4236 domain-containing protein	-
F7R60_RS06450	1364359..1364892	+	534	WP_000719143.1	hypothetical protein	-
F7R60_RS06455	1364904..1365305	+	402	WP_000758222.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1336147..1387674	51527

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6682.88 Da
• Isoelectric Point: 10.6602

>T141035 WP_000838147.1 NZ_CP044519:1363067-1363249 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Nucleotide

• Length: 183 bp

>T141035 NZ_CP059723:574343-574519 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14605.61 Da
• Isoelectric Point: 4.4169

>AT141035 WP_000966690.1 NZ_CP044519:1363314-1363718 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT141035 NZ_CP059723:574565-574981 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Toxin

• AlphaFold DB: A0A5Q0RPK1

Antitoxin

• AlphaFold DB: A0A335N5K1