Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpIK/-
Location 2777731..2778302 Replicon chromosome
Accession NZ_CP044513
Organism Leptospira interrogans serovar Canicola strain 611

Toxin (Protein)


Gene name chpK Uniprot ID -
Locus tag F8B19_RS12420 Protein ID WP_181016507.1
Coordinates 2777731..2777961 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name chpI Uniprot ID A0A8I0U107
Locus tag F8B19_RS12425 Protein ID WP_000844756.1
Coordinates 2778054..2778302 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8B19_RS12395 2773032..2773436 - 405 WP_001974506.1 pyridoxamine 5'-phosphate oxidase family protein -
F8B19_RS12400 2773433..2773900 - 468 WP_000060052.1 hypothetical protein -
F8B19_RS12410 2774704..2775639 + 936 WP_000004530.1 ornithine carbamoyltransferase -
F8B19_RS12415 2775779..2776771 + 993 WP_000041094.1 aldolase -
F8B19_RS12420 2777731..2777961 - 231 WP_181016507.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
F8B19_RS12425 2778054..2778302 - 249 WP_000844756.1 ribbon-helix-helix domain-containing protein Antitoxin
F8B19_RS12440 2780077..2780373 - 297 WP_000477061.1 helix-turn-helix domain-containing protein -
F8B19_RS21080 2780527..2780986 + 460 Protein_2279 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-71)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(2-41)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8093.39 Da        Isoelectric Point: 9.8976

>T141030 WP_181016507.1 NZ_CP044513:c2777961-2777731 [Leptospira interrogans serovar Canicola]
INTIVSIAITSNLNLSEAPGNVLISKKDSSLSKDSVINVSQIVTLDKERFLNKAGKLKSNKLGEVEIGLKLVTGLD

Download         Length: 231 bp

>T141030 NZ_CP059718:19112-19270 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9324.75 Da        Isoelectric Point: 10.3019

>AT141030 WP_000844756.1 NZ_CP044513:c2778302-2778054 [Leptospira interrogans serovar Canicola]
MKTAISIPDELFKAAEKIAKKLGIPRSQLFAKALEEFIQSHSKESVTEKLNKIYSNKSKETKNNITDLSVESLRKSLKND
SW

Download         Length: 249 bp

>AT141030 NZ_CP059718:19001-19066 [Escherichia coli]
AGAAGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References