141019

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 588675..589153 Replicon chromosome
Accession NZ_CP044497
Organism Haemophilus influenzae strain PittGG

Toxin (Protein)


Gene name VapD Uniprot ID A0A0H3PEZ5
Locus tag F8B64_RS02955 Protein ID WP_005656500.1
Coordinates 588875..589153 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0K9KX05
Locus tag F8B64_RS02950 Protein ID WP_012055040.1
Coordinates 588675..588866 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F8B64_RS02930 584902..585882 + 981 WP_012055042.1 DNA polymerase III subunit delta' -
F8B64_RS02935 585921..586703 + 783 WP_012055041.1 YchF/TatD family DNA exonuclease -
F8B64_RS02940 586730..587254 + 525 WP_005669286.1 DUF1523 family protein -
F8B64_RS02945 587305..588603 + 1299 WP_074040071.1 hemolysin family protein -
F8B64_RS02950 588675..588866 + 192 WP_012055040.1 DUF5397 family protein Antitoxin
F8B64_RS02955 588875..589153 + 279 WP_005656500.1 virulence-associated protein VapD Toxin
F8B64_RS02960 589246..589776 + 531 WP_005686915.1 hypothetical protein -
F8B64_RS02965 589848..591347 + 1500 WP_012055039.1 fused PTS fructose transporter subunit IIA/HPr protein -
F8B64_RS02970 591349..592290 + 942 WP_012055038.1 1-phosphofructokinase -
F8B64_RS02975 592292..593962 + 1671 WP_012055037.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 5.7408

>T141019 WP_005656500.1 NZ_CP044497:588875-589153 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQQAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

>T141019 NZ_CP059711:c97998-97648 [Enterobacter hormaechei]
ATGTGGACGGTACTGTTTAGTAAGGTATTCGAGCAATGGTTGCTTGAACAGGAAGATGGGTTGCAGGAAAAGGTACTGGC
AGACCTGTTAAATCTACAGAATTATGGACCGCGTCTTCCTCGTCCCTATGCGGATACCGTTAAGGGCTCACAGTATAAGA
ATATGAAAGAGTTACGTATTCAATATGCGGGTCGCCCGGTTCGTGCGTTCTTCGCGTTTGATCCTGTACGTCAGGCCATT
GTGCTTTGCGCGGGCGATAAGCGTAATGACAAAACCTTTTATGAAAAACTGATTCGCATTGCAGATGCCGAATTCACCCA
TCATCTGACAAGCCTGGAGGCAGCCAAGTGA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7018.97 Da        Isoelectric Point: 3.9930

>AT141019 WP_012055040.1 NZ_CP044497:588675-588866 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDALVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp

>AT141019 NZ_CP059711:c97651-97352 [Enterobacter hormaechei]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGCTCACCGGAAAGCCAACAGCGCATTCAGGAGATGGCAGAGGAAATGTT
CCTCGAAACCGGTCTGCAACTTCTGCGTGAAGAGCTCCAGCTTTCGCAAAAACATGTCGCCGCTCTTATGGGCGTAAGTC
AACCTGCGGTAACACAGCTGGAGCAGCGTGGAAACGATCTGAAGATTGCTACGCTTAAGCGTTACATCGAAGCGATGGGC
GGAAAACTTAGCATTAACGTGGAACTACCCACTGGCAAGCAGGTTGCGTTTCATCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3PEZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A0K9KX05

References