Detailed information of TA system TA141018

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 384653..385301
• Replicon: chromosome
• Accession: NZ_CP044497
• Organism: Haemophilus influenzae strain PittGG

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: A0A0Y7JUP0
• Locus tag: F8B64_RS01895
• Protein ID: WP_005694481.1
• Coordinates: 384653..385012 (+)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: F8B64_RS01900
• Protein ID: WP_005650837.1
• Coordinates: 385005..385301 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F8B64_RS01890	381336..384383	+	3048	WP_012055158.1	TonB-dependent hemoglobin/transferrin/lactoferrin family receptor	-
F8B64_RS01895	384653..385012	+	360	WP_005694481.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F8B64_RS01900	385005..385301	+	297	WP_005650837.1	helix-turn-helix transcriptional regulator	Antitoxin
F8B64_RS01905	385462..387378	+	1917	WP_012055157.1	ABC transporter ATP-binding protein	-
F8B64_RS01910	387388..387924	+	537	WP_012055156.1	topoisomerase DNA-binding C4 zinc finger domain-containing protein	-
F8B64_RS01915	387940..388491	+	552	WP_012055155.1	threonylcarbamoyl-AMP synthase	-
F8B64_RS01920	388495..389301	+	807	WP_012055154.1	shikimate dehydrogenase	-
F8B64_RS01925	389313..390071	+	759	WP_012055153.1	DUF3800 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (36-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-89)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 14321.67 Da
• Isoelectric Point: 10.1408

>T141018 WP_005694481.1 NZ_CP044497:384653-385012 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Nucleotide

• Length: 360 bp

>T141018 NZ_CP059710:4680950-4681231 [Xanthomonas oryzae pv. oryzicola]
ATGATCAGGAGCTTTATCGACAAGGACGCCGAAAAGATCTGGCTGGGTGAGCGTTCCCGCCGGTTGCCTGCCGACATCCA
ATTGGTCGCGCGCCGCAAGTTGCGCATGCTCAATGCCGCCGCGCATCTCGACGATCTGCGGATCCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGGCGCGGCCAGTACAACATCCGGATCAACGATCAATGGCGCATCTGCTTCCGATGGATG
GAAGGCGATGTGGTCCAGGTCGAAATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11092.94 Da
• Isoelectric Point: 10.3139

>AT141018 WP_005650837.1 NZ_CP044497:385005-385301 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Nucleotide

• Length: 297 bp

>AT141018 NZ_CP059710:4681249-4681539 [Xanthomonas oryzae pv. oryzicola]
ATGACGGTCCTACCCAATATCCATCCTGGCGACATTCTGCTTGAGGAGTTTCTCGAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGCACCTCCGAGCGCTTCTGGCTGGGCCTGCAGGCCGACTACGAGCTGGAACAGGCG
CATCGCGCGCTGGGCGATTTGCCGGCACGGATCAAGCGGCTGGCGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0Y7JUP0