Detailed information of TA system TA141017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 46035..46666
• Replicon: chromosome
• Accession: NZ_CP044497
• Organism: Haemophilus influenzae strain PittGG

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: F8B64_RS00230
• Protein ID: WP_005648013.1
• Coordinates: 46268..46666 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q4QLV9
• Locus tag: F8B64_RS00225
• Protein ID: WP_005648011.1
• Coordinates: 46035..46268 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F8B64_RS00200	41515..42717	-	1203	WP_012055320.1	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC	-
F8B64_RS00205	42880..43545	+	666	WP_074039347.1	DNA repair protein RadC	-
F8B64_RS00210	43759..43995	+	237	WP_005542826.1	50S ribosomal protein L28	-
F8B64_RS00215	44007..44177	+	171	WP_005613503.1	50S ribosomal protein L33	-
F8B64_RS00220	44524..45888	+	1365	WP_012055319.1	diaminobutyrate--2-oxoglutarate transaminase	-
F8B64_RS00225	46035..46268	+	234	WP_005648011.1	type II toxin-antitoxin system antitoxin VapB2	Antitoxin
F8B64_RS00230	46268..46666	+	399	WP_005648013.1	tRNA(fMet)-specific endonuclease VapC	Toxin
F8B64_RS00235	46686..48221	+	1536	WP_012055318.1	L-2,4-diaminobutyrate decarboxylase	-
F8B64_RS00240	48453..49268	+	816	WP_012055317.1	DNA-formamidopyrimidine glycosylase	-
F8B64_RS00245	49342..50364	-	1023	WP_005651554.1	outer membrane-stress sensor serine endopeptidase DegS	-
F8B64_RS00250	50365..51483	-	1119	WP_012055316.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

• SpoVT-AbrB domain (7-56)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15073.38 Da
• Isoelectric Point: 8.0514

>T141017 WP_005648013.1 NZ_CP044497:46268-46666 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAGIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Nucleotide

• Length: 399 bp

>T141017 NZ_CP059710:c2732626-2731775 [Xanthomonas oryzae pv. oryzicola]
ATGAGCAACGTCGCCGCTTCCGTGCGCGCCCGCTTGCGGGGCGTCGCCAAGGCGCAGGGCGTGGATTTCAATCAGGTGCT
GGTGCGCTTCGCGCTGGAGCGCATCCTTTACCGCCTGAGCCAGTCCGAGCACGCGGATCGTTTCCTGCTCAAGGGCGCGC
TGCTGTTCACGCTCTGGTATGACATGCCGCACCGGGCCACGCGCGACGCCGACCTGCTGGGCTTCGGCGCGAGCGATCTG
GAGTCCGTGGCCCAGACCTTCCGCGACATCGCCAGCGTCGCCGTGGACGACGGCATCGTGTTCGACCCGGCCTCGGTCGT
CGCAGAAGAAATTCGCAAGGACGCCGGATACGCCGGGGCGCGCATCCTCATCGGCGGCGAGCTGGCCAAGGCGCGGTGCA
GGACGCAGATCGACGTTGGCTTCGGCGATGCGGTCACACCGGCTCCGGTGCACTCGGTCTATCCGGTGTTGCTGGAAGAT
CTGCCTGCGCCTCGCCTGCGCACCTATCCCGTCTACACCGTCATCGCGGAAAAGCTCCACGCCATCGCGCTTCTGGGTAT
GACCAACAGTCGGATGAAGGATTACCTCGACCTGTCGGTGCTGCTGGAACGCGAATCCCTGGACATCGATCTGCTGGCGC
AAGCGGTGAAGGCCACTTTCGAGCGACGCGGCATGGCCGTGCCCGCTGCTCTGCCGATCGGCATGACCGACGAGTTCGCG
CACGACACGTCTCGGCAGGCGCTGTGGCAGGCATTCCTCAAGAAGAACGAACTCGCCCCCGAACCCCTGGCTGCCATCGT
GGTTCGACTGCGGGCGGCCTTGGAACCAGCGTTGCACCGGGCTGCTCGATGA

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8880.98 Da
• Isoelectric Point: 4.4013

>AT141017 WP_005648011.1 NZ_CP044497:46035-46268 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Nucleotide

• Length: 234 bp

>AT141017 NZ_CP059710:c2733228-2732623 [Xanthomonas oryzae pv. oryzicola]
ATGCTTTCCGACACCCACACCCAGCGCGTCCTCGATCTGGCCAGCCAGAAAGGACTGCTGCGCGCCAGCGATCTGGACGC
CATCAATGCGCCCCGGGTCGTTCTCACGCGCCTGACCGCTGCTGGCGTTCTGGAAAGGGTCGGACGCGGGCTGTACCGCC
TGCCGGACGCGCAGGGATCGGAATTCGAGAGTCTCGCGGCCATCGCCACCAAGGTGCCACAAGCCGTGTTCTGCCTGCTG
ACTGCGCTGCAGTTCCACGAACTGACCACGCAACTGCCGCGCCAGATCTGGATCGCCATGCCGCGCGGCAGTCACGCGCC
CCGGATCGGCTATCCGCCGGTCAAGATGGTTCAGATGACCGGCGACGTCTACGCTGCAGGCATCGAGGAGCACCTGCGCG
ACGGCGTGAGGCTGCGCGTGTACGGTGCGGCCAAGACGGTCGTGGACTGCTTCAAGCACCGCAACAAGATCGGCCTGGAC
GTGGCGCTGGAGGCGCTGAAGGACGTGCGCGCCAAACGCAAGGCCACTGCGGACGACCTGTGGCGCTTTGCTACGGTCTG
CCGCGTGGCCAACGTGATGCGCCCCTATCTGGAGGCGGTCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A806DGS0