Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1355064..1355650 Replicon chromosome
Accession NZ_CP044495
Organism Streptococcus mutans strain UA140

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag FSA28_RS06725 Protein ID WP_002290797.1
Coordinates 1355459..1355650 (-) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag FSA28_RS06720 Protein ID WP_032526274.1
Coordinates 1355064..1355441 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSA28_RS06710 1351055..1351339 - 285 WP_002262720.1 helix-turn-helix transcriptional regulator -
FSA28_RS06715 1351655..1352548 + 894 WP_002276322.1 XRE family transcriptional regulator -
FSA28_RS06720 1355064..1355441 - 378 WP_032526274.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FSA28_RS06725 1355459..1355650 - 192 WP_002290797.1 type II toxin-antitoxin system HicA family toxin Toxin
FSA28_RS06730 1355747..1356409 - 663 WP_002290796.1 type II-A CRISPR-associated protein Csn2 -
FSA28_RS06735 1356399..1356743 - 345 WP_002263547.1 CRISPR-associated endonuclease Cas2 -
FSA28_RS06740 1356740..1357606 - 867 WP_002290795.1 type II CRISPR-associated endonuclease Cas1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-61)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-107)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7227.53 Da        Isoelectric Point: 10.2062

>T141016 WP_002290797.1 NZ_CP044495:c1355650-1355459 [Streptococcus mutans]
MPLTGKELARLAINNGWEEVRVRESHHDFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Download         Length: 192 bp

>T141016 NZ_CP059710:c908084-907524 [Xanthomonas oryzae pv. oryzicola]
CTGCACTGTGGTAATGCCGCTGTGCAGAGTTCGAGTTGGGTGAGCATCGGCAACCCAGAACTGATCGACAAGCGCTCCAG
TCATCCTGTACCGCTTCCACCGGGCGGCTTCTCAAACGATTACGTGCCGTTCTACTTCACTCCGTTTTTGCCGATGCTGC
GCAACATCCATACCGCCTGGGGTGGAATCCAAAGGCGGCCTAACGAAGACATCGTCATCCTTGTTTCCAGCTTGCATCAT
GTCGCCGAACGCCGATGGCCGTTTCTGTTTACTGACAGCCACGCCTACTGCCAGTTGGCGAGCTTCTATTCCGATTTATC
CGATCTCGACAAGATCGACTGGCCGTTGCTCCAAGCACGCGATTTCCGGCGCGACCCAGACGACCCAGCCAAGTTCGAGC
GCTATCAGGCCGAGGCCCTGATTCACCGACACGTGCCGCTTGATGGCCTGCGCGGCATTGTGTGTCATACGGATGGTTTG
CAACAGACCATCGAGCGGCAACTCCAAGAGCGAAACCTGAAATTGCCGGTTCATACCCGCACCGGGTGGTATTTCCGATG
A

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14321.29 Da        Isoelectric Point: 4.5628

>AT141016 WP_032526274.1 NZ_CP044495:c1355441-1355064 [Streptococcus mutans]
MLKSYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALERKLQL

Download         Length: 378 bp

>AT141016 NZ_CP059710:c907527-906457 [Xanthomonas oryzae pv. oryzicola]
ATGATCACGTTCACACAAGGCAATCTACTGGAGTCTGGCGCAGAGGCGCTGGTCAACACCGTCAACACCGTCGGCGTGAT
GGGCAAGGGCATCGCGCTGATGTTCAAGGAGCGCTTCAAGGAGAACTTCCTCCGATATGCCGCCGCCTGCAAAGACAACC
AAGTGCGCATTGGCAAAATTTTCGTCACCGAAGTCAACGAACTGGACGGGCCACGCTGGATCATCAATTTTCCGACCAAA
CAGCACTGGCGTGGCGATTCCCGCATCGAATGGATCACTGAAGGATTGCAGGACTTGCACCGTTTTCTGATCGAGAACAA
AGTCAAATCCATTGCCATCCCGCCACTGGGCGCGGGCAATGGAGGATTGGACCGGGCCGACGTGCGCCCACTGATCGAAG
AAGTACTAGCAGGTTTGGATACAGACATCCTCGTGTTCGAGCCTACCTTGAAGTATCAGAACGTTGCCAAGCGCTCCGGC
GTGGAAAAATTGACCCCGGCACGCGCCTTGATTGCCGAGCTGGTACGTCGTTACTGGGTGCTAGGTATGGAATGCGGCCT
GTTGGAAATCCAGAAACTGGCGTGGTTCCTTGAACGCAACATCGAGCGAGCGGGCTTGCCTGAGCTTGATTTGCGCTTTT
CAGCACACAAGTACGGCCCTTATGCCGACCGTCTACGCCATCTTCTGAACGGGCTGGACGGAAGCTACCTGCATTGTGAC
AAACGGATCAGCGACGCCGACCCGCTGGACGTGATCTGGTTCGACGACAATCGCAAAAGCTTCGTACAGACCTACCTAAA
GAGCGAGGCGAAACAGTACATTCCAGCACTGGAAGCTACTGCCGCCTTGATCGATGGTTTTGAATCTCCTTTTGGCATGG
AGTTGTTGGCGACAGTTGACTGGCTGATTGTGCAGGAAGGTATCTCTGCGCAAGTTGCCGACGTGCGTGAAGGCATACGC
CACTGGCCAGGTGATCAGGAGGCAGCGGCGCGAAAGGACAGACTGTTCGATGACCGCGCCTTGGGGATCGCGCTGAAACG
ACTGGCATCAGGTGCAATCGCAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References