Detailed information of TA system TA141015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 910857..911394
• Replicon: chromosome
• Accession: NZ_CP044495
• Organism: Streptococcus mutans strain UA140

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FSA28_RS04525
• Protein ID: WP_002291480.1
• Coordinates: 911116..911394 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q8DUM4
• Locus tag: FSA28_RS04520
• Protein ID: WP_002262888.1
• Coordinates: 910857..911129 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FSA28_RS04505	907332..907913	+	582	WP_002291494.1	hypothetical protein	-
FSA28_RS04510	907915..909675	+	1761	WP_088741843.1	restriction endonuclease subunit S	-
FSA28_RS04515	909687..910784	+	1098	WP_002291483.1	hypothetical protein	-
FSA28_RS04520	910857..911129	+	273	WP_002262888.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
FSA28_RS04525	911116..911394	+	279	WP_002291480.1	type II toxin-antitoxin system YafQ family toxin	Toxin
FSA28_RS04530	911397..914444	+	3048	WP_002291479.1	type I restriction endonuclease subunit R	-
FSA28_RS04535	914657..915031	+	375	WP_002262891.1	DUF1149 family protein	-
FSA28_RS04540	915037..915882	+	846	WP_002266545.1	DegV family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-76)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10726.80 Da
• Isoelectric Point: 10.2430

>T141015 WP_002291480.1 NZ_CP044495:911116-911394 [Streptococcus mutans]
MLKIKQTRQFKKSLKKVVKQGKDINKLFAIVELLYQKSELPLALRDHELKGKWKGIRELHIESDWLLAYQVLDNELVLLL
IDTGSHAQMLGM

Nucleotide

• Length: 279 bp

>T141015 NZ_CP059710:619564-620829 [Xanthomonas oryzae pv. oryzicola]
ATGAAAAACAAGACAGACATTGCTGGCATAGCCGGACTTTCTACGTCTCATGTTTCCTTTGATGACGCAGAATCCAAAAG
CGTCCTAGATGGATCAACACAGTCTACGCCGGAGTACAAATTCCAGACCCCGCTTGATCAGTTGCCGGCTAGGCCCGCTG
GTCCGAAGAGCAGTAACACAACTGATGCTTACATTCATGAATCACTGCCGCATTCGGTTCCAATCGCAGGTGCATCGACC
TCCGCGGCGACACATCAACAGGCTACTCAGCGTAAAGGCACCGATGAGATCTATGGTTTGGGCAGCCTCCCATCTGCTGG
TCCAGAGCGATGGGATTATCTTGCGAATCCGGGGAACTGGCATCCCGAACGCCGTAAGTTACACGAAAAGCTATTAGATC
AAGCGCGATCTTCTGCCTTGACCCTGGCAGAATCCCTTGAGAGTGATGGCTGCCAACCGACATTGTTTGCGCTGCGCGGA
AATACCGCAACGGGTAAAACACGGATTGCGACAAAAAAGATCCCGGTGCTCGCAGCAGCTCTGAAGAAGACAGGTGGGAA
AGGTTGCGTGAATCCAGATGTATTCAAGAGTTCGCTTGCGAAATCCGAGGCAGGCGCCAAGATATTTAGTTCGGCACAAG
TGCATAGCGAGTCATCTTTTCTTGCCGACCGGTTTGAAGGCGGACTTCGCTCTCAAAAGACGGGCAGCGGTGCAATCGCT
AGCATTGTTGTCGACAAGCGCTTGTCAAGAGCGTACGAAATTGATAGCTACATACAACTAGCGAAAGAAACCGGTAGAAA
AGTGGAATTGTGCGATATCGACGCGCCCCTAGAGAATTCTTTGGTGGGAGTTTTGCAGCGAAAACCGGAAGGTGAAGATC
CTAGGCCTCCGTACCCTGTAGTCTCGAGTGGATTTGTAGCCGTACGGAGCAATAGAATGTACGTGATAGACAGGTTCATT
GCCGATCCGAGCCTGGGAAACTACCGACTATTCGGAACAGCTGAAGATGGTGAGAAGGTCATGGTTGCTAGCGTGATTGG
CGGTGAGTTTAGTGTAGAGAATGCTGAGTTGTATGAAAAAATCACGTCCCCACAGCTCTCGGTTACGGGCGATTTGGCTG
ATAAGGTAATCGACAAGGAATTGATTGATCGTCTGAAAAATAATATAGCTGACCCCGAGCGGGCGGCCAAGACGCAAGCC
GCCCTGGAAAAATACAGCGGTAAGTCATGGTCGGCCGCGCTAGCTGCTCACAGCGAGCTAATTTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10051.41 Da
• Isoelectric Point: 4.4482

>AT141015 WP_002262888.1 NZ_CP044495:910857-911129 [Streptococcus mutans]
MVVKNKANINIKIDLEDKAAADAIFAHMGLTTSAAVNMFIKRVIDDQALPFTPRVKNTLDIALEQAKNDDVETFDSFDDW
KSEMSAYAKD

Nucleotide

• Length: 273 bp

>AT141015 NZ_CP059710:620847-621143 [Xanthomonas oryzae pv. oryzicola]
ATGAAAACTTTGACAGGCGCAGACGCACTCGAATTTCATAAGAAGCTTAAGGAACGTAATAAAGCCTTACATGCTTCCGA
CCTCGAGTTAGCACTGGTGCACGCCGATGCTGTCGGCAAAGAACGGTTCGATCTCGAGGAGCTGGAGAAAATTTGCGATA
CCAGCGATGCGGGGCGCCTTACTGATGCGAAAGAGCGACACGACATATATGAAAGGATGTACTACGTTGAGTATCCCAAC
GTTATGACGTTAAAGGAATTCGCTCATATCGTCGAGACACTTTCCTCGTGGTCATGA

Structures

Antitoxin

• AlphaFold DB: Q8DUM4