Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 172356..172927 Replicon chromosome
Accession NZ_CP044495
Organism Streptococcus mutans strain UA140

Toxin (Protein)


Gene name mazF Uniprot ID A0A2J9QC66
Locus tag FSA28_RS00930 Protein ID WP_002265705.1
Coordinates 172595..172927 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2J9QC51
Locus tag FSA28_RS00925 Protein ID WP_002264866.1
Coordinates 172356..172601 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSA28_RS00900 167463..168104 + 642 WP_002292082.1 hypothetical protein -
FSA28_RS00905 168420..169277 + 858 WP_002292084.1 replication initiation factor family protein -
FSA28_RS00910 169583..170764 + 1182 WP_002292086.1 plasmid recombination protein -
FSA28_RS00915 170931..171392 + 462 WP_002292087.1 hypothetical protein -
FSA28_RS00920 171558..171656 + 99 WP_002282917.1 type I toxin-antitoxin system Fst family toxin -
FSA28_RS00925 172356..172601 + 246 WP_002264866.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FSA28_RS00930 172595..172927 + 333 WP_002265705.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FSA28_RS00935 173125..173916 - 792 WP_002267803.1 DUF4037 domain-containing protein -
FSA28_RS00940 174230..175990 + 1761 WP_002292100.1 PDZ domain-containing protein -
FSA28_RS00945 175992..176609 + 618 WP_002270664.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

Antitoxin PemI-like

(1-81)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12664.56 Da        Isoelectric Point: 6.4634

>T141014 WP_002265705.1 NZ_CP044495:172595-172927 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T141014 NZ_CP059710:389485-389619 [Xanthomonas oryzae pv. oryzicola]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9255.55 Da        Isoelectric Point: 4.3021

>AT141014 WP_002264866.1 NZ_CP044495:172356-172601 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Download         Length: 246 bp

>AT141014 NZ_CP059710:389258-389410 [Xanthomonas oryzae pv. oryzicola]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QC66

Antitoxin

Source ID Structure
AlphaFold DB A0A2J9QC51

References