Detailed information of TA system TA141013

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 162364..163325
• Replicon: chromosome
• Accession: NZ_CP044495
• Organism: Streptococcus mutans strain UA140

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: -
• Locus tag: FSA28_RS00850
• Protein ID: WP_002264864.1
• Coordinates: 162364..162879 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: A0A829BWH5
• Locus tag: FSA28_RS00855
• Protein ID: WP_002269854.1
• Coordinates: 162879..163325 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FSA28_RS00825	157781..158518	+	738	WP_002263001.1	MerR family transcriptional regulator	-
FSA28_RS00830	158554..159546	-	993	WP_002269856.1	BtrH N-terminal domain-containing protein	-
FSA28_RS00835	159735..160289	-	555	WP_002262999.1	PadR family transcriptional regulator	-
FSA28_RS00840	160602..161348	+	747	WP_002291851.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
FSA28_RS00845	161372..162232	+	861	WP_002265709.1	DegV family protein	-
FSA28_RS00850	162364..162879	+	516	WP_002264864.1	hypothetical protein	Toxin
FSA28_RS00855	162879..163325	+	447	WP_002269854.1	hypothetical protein	Antitoxin
FSA28_RS00860	163322..163516	+	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
FSA28_RS00870	163909..164355	+	447	WP_002262993.1	50S ribosomal protein L13	-
FSA28_RS00875	164380..164772	+	393	WP_002262992.1	30S ribosomal protein S9	-
FSA28_RS00880	164894..166043	-	1150	Protein_142	site-specific integrase	-
FSA28_RS00885	166110..166673	-	564	WP_002292078.1	helix-turn-helix domain-containing protein	-
FSA28_RS00890	166834..167112	+	279	WP_002292079.1	hypothetical protein	-
FSA28_RS00895	167126..167449	+	324	WP_002292080.1	replication initiator protein A	-
FSA28_RS00900	167463..168104	+	642	WP_002292082.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Entericidin A/B (23-42)

Antitoxin

• Entericidin A/B (23-42)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19540.17 Da
• Isoelectric Point: 9.8779

>T141013 WP_002264864.1 NZ_CP044495:162364-162879 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKRFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Nucleotide

• Length: 516 bp

>T141013 NZ_CP059710:389258-389410 [Xanthomonas oryzae pv. oryzicola]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16998.26 Da
• Isoelectric Point: 9.5767

>AT141013 WP_002269854.1 NZ_CP044495:162879-163325 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Nucleotide

• Length: 447 bp

>AT141013 NZ_CP059710:389485-389619 [Xanthomonas oryzae pv. oryzicola]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A829BWH5