Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 176295..176866 Replicon chromosome
Accession NZ_CP044493
Organism Streptococcus mutans strain MD

Toxin (Protein)


Gene name mazF Uniprot ID A0A2J9QC66
Locus tag FSA40_RS00935 Protein ID WP_002265705.1
Coordinates 176534..176866 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q8DW96
Locus tag FSA40_RS00930 Protein ID WP_002262990.1
Coordinates 176295..176540 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FSA40_RS00905 171872..172246 - 375 WP_002285664.1 hypothetical protein -
FSA40_RS00910 172440..173150 + 711 WP_002285665.1 hypothetical protein -
FSA40_RS00915 173213..174156 + 944 Protein_151 adenine-specific DNA-methyltransferase -
FSA40_RS00920 174180..175259 + 1080 WP_050556743.1 hypothetical protein -
FSA40_RS00925 175259..175756 + 498 WP_151416473.1 hypothetical protein -
FSA40_RS00930 176295..176540 + 246 WP_002262990.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
FSA40_RS00935 176534..176866 + 333 WP_002265705.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FSA40_RS00940 177064..177855 - 792 WP_002280060.1 nucleotidyltransferase domain-containing protein -
FSA40_RS10335 178022..178378 + 357 Protein_157 transposase family protein -
FSA40_RS00950 178557..179777 + 1221 WP_151416166.1 PTS sugar transporter subunit IIC -
FSA40_RS00955 179755..180603 + 849 WP_151416167.1 alpha/beta hydrolase -
FSA40_RS00960 180745..181347 + 603 WP_002269739.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 178022..178150 128


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-107)

Antitoxin

SpoVT-AbrB domain

(7-50)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12664.56 Da        Isoelectric Point: 6.4634

>T141012 WP_002265705.1 NZ_CP044493:176534-176866 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHEQKGYRPYICLNHSIVTKYSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Download         Length: 333 bp

>T141012 NZ_CP059692:2348908-2349111 [Aureimonas sp. LMG 31693]
ATGAGCCCGAAGCGACAGGTTGAACGCCCCAAGGACATCATCAAGCGATTGCTCGGCGATGGCTGGACGGAGCGGAAGGG
AAAGGGGGACCACCGCAATTTCACCAAGCCCGGTCACGGGGTGGTCACGGTGGACACGGGAGTGAAGGAGATACCGATCG
GCACCCTTCGCAACATCTACAGAACGGCGGGCTGGGGCTGGTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9241.52 Da        Isoelectric Point: 4.3021

>AT141012 WP_002262990.1 NZ_CP044493:176295-176540 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNIPELTVEDLFKDYQGEPVNVTPALFESVGNEQ
W

Download         Length: 246 bp

>AT141012 NZ_CP059692:2349151-2349558 [Aureimonas sp. LMG 31693]
ATGACCAACGTCGTCGCATTGATCCACGGAGAGGCCGGCACCTACGGCATCTCCTTCCCAGACTTCCCCGGCGCGGCGTC
CGGCGGCGCCACCGTTGACGAGGCGCTGGCGCGCGGCCGCGCGTTGCTCGCCACCCATATCGAGGCACTGACGGAAGAGA
AGGTCGCCCTTCCCGCCCTGCGCACGCTGGAGGAGGTCCGCGCCGATCCCGCGCTCGCGGAGGACTTCGCCGATGCCGTC
GCCGTCACCCTGGTGCCGGCGGACCTGCCCGGCCGCGCACGGCAGTTCACGATCTCGATGGACGAGAACCTGATGGCTCG
CATCGACGTGCAGGCCAAGGCCCTCGGCGAGAACCGCTCGCGCTATCTCGCCAACGCCGCGCGCAATCGCCTGCGGGAGG
ATGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QC66

Antitoxin

Source ID Structure
AlphaFold DB Q8DW96

References