Detailed information of TA system TA141011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 165320..166281
• Replicon: chromosome
• Accession: NZ_CP044493
• Organism: Streptococcus mutans strain MD

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: -
• Locus tag: FSA40_RS00850
• Protein ID: WP_151416162.1
• Coordinates: 165320..165835 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: A0A829BWH5
• Locus tag: FSA40_RS00855
• Protein ID: WP_002269854.1
• Coordinates: 165835..166281 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FSA40_RS00825	160737..161474	+	738	WP_002263001.1	MerR family transcriptional regulator	-
FSA40_RS00830	161510..162502	-	993	WP_151416160.1	BtrH N-terminal domain-containing protein	-
FSA40_RS00835	162691..163245	-	555	WP_002275401.1	helix-turn-helix transcriptional regulator	-
FSA40_RS00840	163558..164304	+	747	WP_002264862.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
FSA40_RS00845	164328..165188	+	861	WP_151416161.1	DegV family protein	-
FSA40_RS00850	165320..165835	+	516	WP_151416162.1	hypothetical protein	Toxin
FSA40_RS00855	165835..166281	+	447	WP_002269854.1	hypothetical protein	Antitoxin
FSA40_RS00860	166278..166472	+	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
FSA40_RS00870	166868..167314	+	447	WP_002262993.1	50S ribosomal protein L13	-
FSA40_RS00875	167339..167731	+	393	WP_002262992.1	30S ribosomal protein S9	-
FSA40_RS00880	167837..169060	-	1224	WP_151416163.1	site-specific integrase	-
FSA40_RS00885	169187..169387	-	201	WP_151416164.1	helix-turn-helix domain-containing protein	-
FSA40_RS00890	169436..170287	-	852	Protein_146	replicative protein	-
FSA40_RS00895	170515..170769	-	255	WP_172964881.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19525.15 Da
• Isoelectric Point: 9.8653

>T141011 WP_151416162.1 NZ_CP044493:165320-165835 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAVQIFTVYQNWSQGSFGHDGHIYLTGEKAMNLLFILTFAVIFLVTA
YKTIQDKREGK

Nucleotide

• Length: 516 bp

>T141011 NZ_CP059690:c3513604-3512291 [Proteus penneri]
ATGGCGAGTCTTGATGTATATATGAATGAATACTATGTGGGGATTTTTACTAAAAAAAGCTCAGGTGCGCATTCATTCCA
ATATACTGAAGATTGGGTTAATCAACCAGGAAGTCGTCCGATCTCTCTTTCGATGCCATTACAACTTCAAGAATATCAAG
GAGACTGTGTCTATAATTTCTTTGATAATCTGTTACCTGATAATACTGAAATTAGAAATCGTATTGTGAGTCGCTATAAT
GCGAATTCAAACCAACCCTTTGATCTTTTAGCGGCTATCGGTGCAGATACTGTTGGTGCATTAAGGTTACTTCCTAGTGG
TAGTACACCCGCGAATATCAAAAAAATAGAATATCACAAACTCGATGACACTGAACTTGAGAAAATTCTACTAGGATATC
AATCCAATACACCACTCGGTATGCTTGAAGAATATCCTGACTTCAGAATTTCTATTGCTGGTGCGCAAGAAAAAACAGCA
TTACTTTTAAAAGATGATCATTGGTGTGTGCCACACAATAATACGCCGACTACACATATTATTAAGCTGCCTATTGGTGT
TATTGAAGGTCATTCTTATACAATGGATTTATCCGATAGTGTAGAAAATGAATATCTTTGTACCTTAATTGCCAAAGAAT
TTGATCTTCCTGTTCCTCACTGCTCTATTATTAAAACAAAAAATATTAAAGCGCTTGCTGTAGAACGTTTTGATAGAAAA
TACTCATCAGATAAATCGTGGATAATACGTTTACCTCAAGAAGATTTTTGCCAAATTCTAAATATACCTTCTGCACTAAA
ATATGAAAATGAAGGGGGCCCTGGCATTATCGATATTATGAAATATTTACTTGGCTCATCAAATGCCGATCAAGACCGTT
TTCATTTTATGAAGGCGCAAGTGCTATTTTGGCTTTTAGCGGCAACAGATGGACATGCAAAGAATTTTTCTGTTTTTATC
AACCAAGAAGGACGTTTTCATCTCGCGCCTCTTTATGACATTATGTCTATCTATCCCAATTTTGGAGGAAAAGGACTTAA
TCCACGAGATGCAAAACTTGCTATGGGATTAAAAGCAAGCCGAGGCAAAAAATACGCAATAGAACAAATTTTTCCTCGCC
ATTTTTACCAAACAGCCGAAGCTGTCGGTTTCGATCCTTCCTTGATGAGCAAGATTCTTCGTTATTTTTATCAAGAAATG
GACGATGTTATACAACGCGTAAAACAGCAATTACCCGAAGATTTCCCTTCTGAGATCAGCAATACAATATTGGATGGAAT
GAAAGCACGCGTTGTTAGATTAGCTAATATTTAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16998.26 Da
• Isoelectric Point: 9.5767

>AT141011 WP_002269854.1 NZ_CP044493:165835-166281 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Nucleotide

• Length: 447 bp

>AT141011 NZ_CP059690:c3513862-3513605 [Proteus penneri]
ATGATTATAATTAACGCCTATCAACTCAGCGTACATCTAAAAGATGTCCGATTAACAAAAAAACTATCTCAAAGTAAAGT
CGCCAAAAAAGTAGGAATTCGACAAGACACCGTGTCCAATTTTGAACTTAATCCTAATTCCACCAAACTAGAAACCTTTT
TCAAACTGCTCTCTGCACTAAATTTAGAGATGGAAATTCATCCTAAAGGTGCTAAAAATAATTTAGCACACAAAAGTGAA
TGGAAAGAGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A829BWH5