Detailed information of TA system TA141010

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/PRK09907-MazE
• Location: 174082..174653
• Replicon: chromosome
• Accession: NZ_CP044492
• Organism: Streptococcus mutans strain T8

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: FSA31_RS00905
• Protein ID: WP_002284727.1
• Coordinates: 174321..174653 (+)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: A0A2J9QC51
• Locus tag: FSA31_RS00900
• Protein ID: WP_002264866.1
• Coordinates: 174082..174327 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FSA31_RS00860	169587..170333	+	747	WP_002284726.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
FSA31_RS00865	170357..171217	+	861	WP_002279204.1	DegV family protein	-
FSA31_RS00870	171349..171864	+	516	WP_002270668.1	hypothetical protein	-
FSA31_RS00875	171864..172310	+	447	WP_002269854.1	hypothetical protein	-
FSA31_RS00880	172307..172501	+	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
FSA31_RS00890	172897..173343	+	447	WP_002262993.1	50S ribosomal protein L13	-
FSA31_RS00895	173368..173760	+	393	WP_002262992.1	30S ribosomal protein S9	-
FSA31_RS00900	174082..174327	+	246	WP_002264866.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
FSA31_RS00905	174321..174653	+	333	WP_002284727.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
FSA31_RS00910	174851..175642	-	792	WP_002284728.1	DUF4037 domain-containing protein	-
FSA31_RS00915	175956..177717	+	1762	Protein_152	PDZ domain-containing protein	-
FSA31_RS00920	177719..178339	+	621	WP_002307135.1	response regulator transcription factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-107)

Antitoxin

• Antitoxin PemI-like (1-81)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12647.62 Da
• Isoelectric Point: 7.9995

>T141010 WP_002284727.1 NZ_CP044492:174321-174653 [Streptococcus mutans]
MVTIKQGSIIKINLDPKQGHKQKGYRPYICLNHSIVTKFSNIAIFAPISNTKRDYPFYVPLEGTESTGKVLLDQLVTIDF
NARDYRYVEDIQEDLLDELLARVKVLFEKG

Nucleotide

• Length: 333 bp

>T141010 NZ_CP059679:c1050138-1049767 [Mammaliicoccus lentus]
ATGAGAAGAGGAGATGTATATCTCGCAGATCTTTCTCCAGTAACTGGTTCTGAACAAGGGGGAACAAGACCAGTCGTTAT
TATACAAAATGACACAGGTAATAGATATAGTCCGACTGTTATTGTAGCAGCGATTACTGGGAAGATTAATAAAGCTAAAA
TACCTACACATGTAGAAATTGAAGCAGCGAAATATAAACTAGATAGAGATTCAGTTATTTTGCTAGAACAAATTAGAACA
ATCGATAAGAAACGGTTGAAAGAAAAATTAACATATTTATCTGATGCAAAGATGAAAGAGGTTGATTCTGCAATTGCAAT
TAGCCTCAATCTCACTTTGCAATATAAATTTGATACATTAGGTAATACATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9255.55 Da
• Isoelectric Point: 4.3021

>AT141010 WP_002264866.1 NZ_CP044492:174082-174327 [Streptococcus mutans]
MQLVINKWGNSSAIRLPKQLVQELQLQTNDVLDYKVSGNKIILEKVNNVPELTVEDLFKDYQGEPVNVTPVLFESVGNEQ
W

Nucleotide

• Length: 246 bp

>AT141010 NZ_CP059679:c1050306-1050139 [Mammaliicoccus lentus]
ATGACATCGTTAACACAAAATCGCAATCAAAGTTTAGAACAAACACTGAAAGAAGGATACCGTTATATGGCTGATTTAAA
TCTCTCCCTTGCGTCTGAAGCATATTATAGTGAATGTGAAGCTTGTGATTCTAATGAGTCACACTTAACTTCTCAACAAG
GTGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A2J9QC51