Detailed information of TA system TA141009

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): SmuAT/-
• Location: 171349..172310
• Replicon: chromosome
• Accession: NZ_CP044492
• Organism: Streptococcus mutans strain T8

Toxin (Protein)

• Gene name: smuT
• Uniprot ID: -
• Locus tag: FSA31_RS00870
• Protein ID: WP_002270668.1
• Coordinates: 171349..171864 (+)
• Length: 172 a.a.

Antitoxin (Protein)

• Gene name: smuA
• Uniprot ID: A0A829BWH5
• Locus tag: FSA31_RS00875
• Protein ID: WP_002269854.1
• Coordinates: 171864..172310 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FSA31_RS00845	166766..167503	+	738	WP_002273490.1	MerR family transcriptional regulator	-
FSA31_RS00850	167539..168531	-	993	WP_002284724.1	BtrH N-terminal domain-containing protein	-
FSA31_RS00855	168720..169274	-	555	WP_002284725.1	PadR family transcriptional regulator	-
FSA31_RS00860	169587..170333	+	747	WP_002284726.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
FSA31_RS00865	170357..171217	+	861	WP_002279204.1	DegV family protein	-
FSA31_RS00870	171349..171864	+	516	WP_002270668.1	hypothetical protein	Toxin
FSA31_RS00875	171864..172310	+	447	WP_002269854.1	hypothetical protein	Antitoxin
FSA31_RS00880	172307..172501	+	195	WP_002262994.1	helix-turn-helix transcriptional regulator	-
FSA31_RS00890	172897..173343	+	447	WP_002262993.1	50S ribosomal protein L13	-
FSA31_RS00895	173368..173760	+	393	WP_002262992.1	30S ribosomal protein S9	-
FSA31_RS00900	174082..174327	+	246	WP_002264866.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
FSA31_RS00905	174321..174653	+	333	WP_002284727.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FSA31_RS00910	174851..175642	-	792	WP_002284728.1	DUF4037 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 172 a.a.
• Molecular weight: 19498.13 Da
• Isoelectric Point: 9.8653

>T141009 WP_002270668.1 NZ_CP044492:171349-171864 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAVQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK

Nucleotide

• Length: 516 bp

>T141009 NZ_CP059676:434397-434816 [Flaviflexus sp. dk850]
ATGATCGTTCTCGACACAAGCGTCATTTCAGAAGTGTTCCGGCCCACTCCTGATCCTGGTGTGCTCGCGTGGCTTGAGTC
CCTCACTGGTGATGTTGCGATCACAACGATCACGCTCGCCGAATTGCTCGCGGGTGTTCGGCGGTTGCCAGCCGGTCGGC
GCAAGAGTGACTTGGAGTTGGCGCTCGATGCCGCACTCGAGCCATATCGGAACACGCGTTCGCTGCTCGCATTCGATGAT
GCGTCTGCTGCGGAGTACGCAGAGGTTCTGCTTGCTCGCGAACAGGCCGAGTTGCCGATCAGTACTCCTGACGCGCAGAT
CGCGGCGATCTGTCGAGCAAACGGCGCGATCTGCGCCACGCGTAACGAGAGAGATTTTGCCGAGACGGGTGTCCAGGTTC
TGAGCCCTTGGACGAGATGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16998.26 Da
• Isoelectric Point: 9.5767

>AT141009 WP_002269854.1 NZ_CP044492:171864-172310 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRESITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK

Nucleotide

• Length: 447 bp

>AT141009 NZ_CP059676:434167-434400 [Flaviflexus sp. dk850]
ATGGCCTCGATTGTTGTCCGCGGACTCGATGAGTCCGTGAAGAACCGTCTTGCCGCGCAGGCAAAAGAGCATGGTCGATC
GATGGAAGCAGAGGTGCGCGAAATCCTGACGCGTGCTTCGTCCCCGCCGCATATCGGCATCGCGCTCATGGGCTTCGCCC
GGGACGTGGGTGAGGTTGAAGAGCTGCAGATTCCTGCTCGGTCTGACACCGCGCGAGCGGTGGACTTCGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A829BWH5