Detailed information of TA system TA140943

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc-RelB
• Location: 12532..13133
• Replicon: chromosome
• Accession: NZ_CP044437
• Organism: Proteus mirabilis strain C74

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: F7R85_RS00055
• Protein ID: WP_049196622.1
• Coordinates: 12532..12915 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1Z1SPN9
• Locus tag: F7R85_RS00060
• Protein ID: WP_004246496.1
• Coordinates: 12912..13133 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7R85_RS00030	7831..8400	+	570	WP_004249768.1	methyltransferase	-
F7R85_RS00035	8456..9943	-	1488	WP_104836109.1	PLP-dependent aminotransferase family protein	-
F7R85_RS00040	10072..10530	+	459	WP_104836110.1	GNAT family N-acetyltransferase	-
F7R85_RS00045	10626..11363	-	738	WP_004249950.1	sel1 repeat family protein	-
F7R85_RS00050	11472..12371	+	900	WP_104836111.1	N-acetylmuramic acid 6-phosphate etherase	-
F7R85_RS00055	12532..12915	-	384	WP_049196622.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
F7R85_RS00060	12912..13133	-	222	WP_004246496.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
F7R85_RS00065	13414..14277	-	864	WP_060557243.1	YicC family protein	-
F7R85_RS00070	14404..15120	+	717	WP_104836112.1	ribonuclease PH	-
F7R85_RS00075	15202..15846	+	645	WP_060557242.1	orotate phosphoribosyltransferase	-
F7R85_RS00080	16164..16769	-	606	WP_004246491.1	nucleoid occlusion factor SlmA	-
F7R85_RS00085	16889..17347	-	459	WP_004246490.1	dUTP diphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (3-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14529.57 Da
• Isoelectric Point: 7.4005

>T140943 WP_049196622.1 NZ_CP044437:c12915-12532 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Nucleotide

• Length: 384 bp

>T140943 NZ_CP059577:17033-17353 [Legionella sp. PC997]
ATGAATCGTGGTGATGTATATTGGGTAAACCTCGACCCTACTACAGGCTCTGAAATCAACAAACTCAGACCTTGCGTTTT
AGTTGGAGCAACACCGATTAATCAAGCAAGACGCACTGTTGTCGTCGTTCCTCTTTCAAGCTCTGCTACAGCCAGACCAC
CAATTACCATCACTGTTTCTTGTCTTGGCAAACAAGTTACCGCAGTTTGTGATCAAATAAGAACGATTGATAAAAGTCGT
TTAAAAAAAGTGGCAGGAAACCTTTCAGATAAAGATTTAAATGCCTTGGATGATGGGTTACGACAAGTTTTATGCCTTTG
A

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8260.23 Da
• Isoelectric Point: 5.5667

>AT140943 WP_004246496.1 NZ_CP044437:c13133-12912 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Nucleotide

• Length: 222 bp

>AT140943 NZ_CP059577:16813-17046 [Legionella sp. PC997]
ATGAATAAAGTTTTAATATCAATACCCGATCAAATCGCTTCTAGAATGAGAGCAGCAATACCTCAGCGACAACGCAGCAA
GGTGATTGCTCATCTTATTGAAAAAGAAATTGAACGACGTGAAAAAGCGCTCTATGAATGCGCTTTAGCTGTTGAAAATG
ATCATGGTTTACAAAATGAAATGAACGATTGGGATATAACGGTTCAAGATGGATTAACTGATGAATCGTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A1Z1SPN9