Detailed information of TA system TA140942

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4144151..4145722
• Replicon: chromosome
• Accession: NZ_CP044436
• Organism: Proteus mirabilis strain C55

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B4F0T8
• Locus tag: F7R84_RS19210
• Protein ID: WP_012368637.1
• Coordinates: 4144151..4145464 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: F7R84_RS19215
• Protein ID: WP_004249771.1
• Coordinates: 4145465..4145722 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7R84_RS19190	4139320..4140123	+	804	WP_004249775.1	energy transducer TonB	-
F7R84_RS19195	4140177..4142138	-	1962	WP_012368635.1	hypothetical protein	-
F7R84_RS19200	4142170..4143099	-	930	WP_004246518.1	metallophosphoesterase	-
F7R84_RS19205	4143284..4143748	-	465	WP_004249773.1	DUF1097 domain-containing protein	-
F7R84_RS19210	4144151..4145464	-	1314	WP_012368637.1	type II toxin-antitoxin system HipA family toxin	Toxin
F7R84_RS19215	4145465..4145722	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
F7R84_RS19220	4146323..4147810	+	1488	WP_104836843.1	SulP family inorganic anion transporter	-
F7R84_RS19225	4147821..4148672	+	852	WP_104836844.1	universal stress protein	-
F7R84_RS19230	4148933..4149526	-	594	WP_104836845.1	hypothetical protein	-
F7R84_RS19235	4149527..4149592	+	66	Protein_3735	EAL domain-containing protein	-
F7R84_RS19240	4149732..4150496	-	765	WP_001389365.1	IS6-like element IS6100 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49670.78 Da
• Isoelectric Point: 6.5023

>T140942 WP_012368637.1 NZ_CP044436:c4145464-4144151 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T140942 NZ_CP059577:c14901-14620 [Legionella sp. PC997]
ATGCTTGAATTAGAGTTGGCGACACAGTTTAAGCGTGATTTGAAAAAGATTACGAAGCAAGGGAAAAGAAGGACGCTCTT
AGACTCTATTGTAGAGCAATTGCAAAAGGAAGAACCCCTGGATCCAAAGCATAAGGATCACAGTCTTTCCGTAAATTGGG
ATGGTTATCGTGAATGTCACATTACCCCCGATTGGTTATTAATTTATAAGACCATTAAAGATGATCGCATACAATTGCTG
CGATTATCACGAACAGGATCACATAGTGATTTGTTTGGGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT140942 WP_004249771.1 NZ_CP044436:c4145722-4145465 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT140942 NZ_CP059577:c15154-14894 [Legionella sp. PC997]
ATGAATAAGGCGGCAACAATTAATGCTCGTATTGAGCCTGCTCTTAAAATGCAGGCAGAAGCGATTTTGCATAAGGTAGG
CTTATCTACAGCCGAGGCGATTCGACTGTTCTATAGCCAGGTCTGTCTCCAAAATGGCCTGCCTTTTGAGGTAAAAATAC
CGAACAAAGAGACAAGAGAGGCCATGGCAGAGCTGGAATCAGGAAAAGGCGAGCGATTTAAAACAATGAAGGATGTATGG
GATTCTGTAGATAATGCTTGA

Structures

Toxin

• AlphaFold DB: B4F0T8

Antitoxin

• AlphaFold DB: B4F0T9