Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3944879..3945680 Replicon chromosome
Accession NZ_CP044436
Organism Proteus mirabilis strain C55

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0E0XS49
Locus tag F7R84_RS18290 Protein ID WP_001094437.1
Coordinates 3944879..3945256 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0E0XTQ1
Locus tag F7R84_RS18295 Protein ID WP_001390338.1
Coordinates 3945303..3945680 (-) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R84_RS18255 3940072..3940755 - 684 WP_004246670.1 hypothetical protein -
F7R84_RS18260 3940845..3941468 - 624 WP_004246669.1 common pilus major fimbrillin subunit EcpA -
F7R84_RS18265 3941608..3941928 - 321 WP_004246668.1 helix-turn-helix transcriptional regulator -
F7R84_RS18270 3942743..3942934 - 192 Protein_3547 virulence RhuM family protein -
F7R84_RS18275 3943247..3944092 - 846 WP_001274561.1 DUF4942 domain-containing protein -
F7R84_RS18280 3944177..3944374 - 198 WP_000772032.1 DUF957 domain-containing protein -
F7R84_RS18285 3944394..3944882 - 489 WP_000761716.1 hypothetical protein -
F7R84_RS18290 3944879..3945256 - 378 WP_001094437.1 TA system toxin CbtA family protein Toxin
F7R84_RS18295 3945303..3945680 - 378 WP_001390338.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
F7R84_RS18300 3945843..3946064 - 222 WP_000692345.1 DUF987 domain-containing protein -
F7R84_RS18305 3946127..3946603 - 477 WP_001535682.1 RadC family protein -
F7R84_RS18310 3946619..3947092 - 474 WP_000855064.1 antirestriction protein -
F7R84_RS18315 3947434..3948252 - 819 WP_001535681.1 DUF945 domain-containing protein -
F7R84_RS18320 3948407..3948565 - 159 WP_001323397.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13986.90 Da        Isoelectric Point: 7.3223

>T140941 WP_001094437.1 NZ_CP044436:c3945256-3944879 [Proteus mirabilis]
MNTLPDTHVREASGCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T140941 NZ_CP059576:3677095-3678393 [Legionella sp. PC997]
ATGCGTAAATTATACATTTTGATGAACAATGAGCTCGTGGGAGAGCTTACCCAGGATAATGCAGGAGGCTTGAGTTTTTT
CTATGTTGAGGACTGGATTTCCAAGCCACATTCGCGACCAGTATCTTTATCGTTGCCGTTAGTAAATCAAAAATTTTCAG
GAGAAGTAGTTTATAACTTTTTTGATAATTTACTTCCCGATAATCCACAGATAAGAGCCAGGATACAAGCTCGTTTTCAA
GCAAAATCATCGCGACCGTTTGATTTATTGGCCTTAATTGGCAGCGATTGTGTTGGGGCAATACAAATTGTTGAACGTAT
TCCTCAGACACAGCGTTTAAGCATTGAAAGTCACGTTGTCAGTGAGGCGGAGATAGCTCGTACTTTACGTTCTTATCAAA
ACTCACCACTGGGAATGGATAAAGAGGATGATGCGTTTAGAATCTCATTAGCAGGTGCTCAGGAAAAAACAGCTTTTCTA
TATTACCAAAATGAATGGCATAAACCATTTGGACCTACACCAACAACTCACATATTCAAATTACCTATTGGATATTTACC
ACATCAAGGAATTGATCTAAGTGAGAGTTGTGAAAATGAACATCTCTGTTTACTACTAGCCAGCAAATTTGGTTTAGATG
TTGCAAAATCAAAAATCTTACAATTCGAAGATGAAAAGGTGCTGGTGGTCGAAAGATTTGATAGAAAATGGAGTCGAGAT
AACCGTTATGTCCTCAGGTTACCGCAAGAAGACCTATGCCAAGCATTGGGTTATTCACCAAATTTAAAATATCAGTCAGA
TGGTGGCCCCGGTATTAAAGAAATTATGCAGTTACTTAACGGCTCACAGCAACCTCAAAAAGATAGAGATGAATTTTTCA
GGGCACAGGTTGTTTACTGGTGCCTTGGCGCTATTGATGCGCATGCCAAAAATTTCAGTATAAGTATACAACCACAAGGC
GGTTACCAGCTCACCCCCTTATACGACATCATTTCAGCATATCCTATCGTGGAACAAAAAAAGTTATCATTTAAGAAATT
GAAAATGGCAATGGCTATATATGGAAAAAATAGTCATTATAAGATTGACGGTATTCAAAAAAGACACTTTCTTGAAACAG
CAAAATACGTTCAATATTCTAAAATTAAAGCAGCTCAGATTTTTGAACAAGTAATTGACCGTATTGATTCTGCTATCGAT
GAAGTCTCAACCCAATTACCAAACCACTTCCCACAAAAGATTGCAGATCCAATCTTCAAAGGGATGAGGGCTTTTAAGGA
GCGTATAATATCCACATAA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13745.44 Da        Isoelectric Point: 5.0463

>AT140941 WP_001390338.1 NZ_CP044436:c3945680-3945303 [Proteus mirabilis]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTITLYAKGLTCEADTLGSCGYAYLAVYPTPAEPAITV

Download         Length: 378 bp

>AT140941 NZ_CP059576:3676856-3677095 [Legionella sp. PC997]
ATGATTATCCGATCAGCAAAAGATTTGGCATTATATTTAAATGACAAGCGCAAGCAACTTAAAATGAGTCAATCGGAAGT
TGCAGATTTAGTGGGTTTGAAACAGGATACCGTATCAAAATTTGAAAATAGTCCCGACAATAGCCGAATTGATACCCTGT
TTAGGATATTGTCCGCCCTAAATTTAAACATTAGTCTTGTTGATAAAGGGCAAAAAACTCATGAAGAGATAGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XS49

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XTQ1

References