140940

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3773390..3774089 Replicon chromosome
Accession NZ_CP044436
Organism Proteus mirabilis strain C55

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag F7R84_RS17510 Protein ID WP_004249093.1
Coordinates 3773390..3773776 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag F7R84_RS17515 Protein ID WP_004246828.1
Coordinates 3773769..3774089 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F7R84_RS17495 3769409..3769990 - 582 WP_004246833.1 DNA-3-methyladenine glycosylase I -
F7R84_RS17500 3770241..3771146 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
F7R84_RS17505 3771156..3773228 + 2073 WP_041701373.1 glycine--tRNA ligase subunit beta -
F7R84_RS17510 3773390..3773776 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F7R84_RS17515 3773769..3774089 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
F7R84_RS17520 3774138..3774572 - 435 WP_004246827.1 hypothetical protein -
F7R84_RS17525 3774565..3775449 - 885 WP_110706881.1 endonuclease/exonuclease/phosphatase family protein -
F7R84_RS17530 3775666..3776952 - 1287 WP_049256516.1 DUF3748 domain-containing protein -
F7R84_RS17535 3777089..3777706 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
F7R84_RS17540 3778008..3778631 + 624 WP_004246821.1 guanylate kinase -
F7R84_RS17545 3778686..3778961 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T140940 WP_004249093.1 NZ_CP044436:3773390-3773776 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T140940 NZ_CP059572:c4276078-4275689 [Actinomadura graeca]
GTGACATGGAAGATCGTCTTGGTGGACGAGGTGCGTGACTGGCTCCATGGGCTGCGGGGGAGCGACCGGGACACCCTGCT
GTCCATCTCGGCCGCGATCGACGTCCTCCAGTTGCGGGGCCCGGCTCTCGGCCGTCCACTGGTCGACACACTGCGCGGTT
CAACGTTGCCGAACTTGAAGGAGCTCAGGCCGGGTTCCCTGGGCAGCTCTGAAGTACGGATACTTTTTGCGTTCGATCCG
GTGCGAGACGCGATCCTTTTAGTCGGGGGAGACAAGTCCAGTGACTGGAACGGCTGGTACAAGGAAGCAATCCCTATTGC
CGAGAAGCGCTACGCGGCCCATCTAGAGGAGCTCGCCGAAGGTCGAGGTCAGGAGAAAGGGAAGAGCTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT140940 WP_004246828.1 NZ_CP044436:3773769-3774089 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT140940 NZ_CP059572:c4275689-4275348 [Actinomadura graeca]
ATGGGTGTCGAGTGGGAGGATCTACGCGACGAGCTTCTCGTCGGCCCCGACGACAAGGCGGAGGTCGCTCGCCGCAGGAA
CAGGCTCCTCGCTGAGGAGCGTGCACATCGACTCGCCGAGGCGAGAAGGCGTCGGCAGCTCACCCAGAAGGACATCGCGG
CCTCGATGGGAGTCACCCAATCGCGGGTCAGCGCCATTGAGCGCGGCAGCCTCGGTCGGGCCGAGCTGGGCACACTGGCT
GCCTATGTTGCGGCTCTCGGGGGACGTCTGGAGATCGTCGCCGACTTCGGAGACGAGAAACTCGTCATCGGCGACAGCGA
TTATCCCGAATCAGGACCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References