Detailed information of TA system TA140940

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3773390..3774089
• Replicon: chromosome
• Accession: NZ_CP044436
• Organism: Proteus mirabilis strain C55

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: F7R84_RS17510
• Protein ID: WP_004249093.1
• Coordinates: 3773390..3773776 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: F7R84_RS17515
• Protein ID: WP_004246828.1
• Coordinates: 3773769..3774089 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F7R84_RS17495	3769409..3769990	-	582	WP_004246833.1	DNA-3-methyladenine glycosylase I	-
F7R84_RS17500	3770241..3771146	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
F7R84_RS17505	3771156..3773228	+	2073	WP_041701373.1	glycine--tRNA ligase subunit beta	-
F7R84_RS17510	3773390..3773776	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
F7R84_RS17515	3773769..3774089	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
F7R84_RS17520	3774138..3774572	-	435	WP_004246827.1	hypothetical protein	-
F7R84_RS17525	3774565..3775449	-	885	WP_110706881.1	endonuclease/exonuclease/phosphatase family protein	-
F7R84_RS17530	3775666..3776952	-	1287	WP_049256516.1	DUF3748 domain-containing protein	-
F7R84_RS17535	3777089..3777706	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
F7R84_RS17540	3778008..3778631	+	624	WP_004246821.1	guanylate kinase	-
F7R84_RS17545	3778686..3778961	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T140940 WP_004249093.1 NZ_CP044436:3773390-3773776 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T140940 NZ_CP059572:c4276078-4275689 [Actinomadura graeca]
GTGACATGGAAGATCGTCTTGGTGGACGAGGTGCGTGACTGGCTCCATGGGCTGCGGGGGAGCGACCGGGACACCCTGCT
GTCCATCTCGGCCGCGATCGACGTCCTCCAGTTGCGGGGCCCGGCTCTCGGCCGTCCACTGGTCGACACACTGCGCGGTT
CAACGTTGCCGAACTTGAAGGAGCTCAGGCCGGGTTCCCTGGGCAGCTCTGAAGTACGGATACTTTTTGCGTTCGATCCG
GTGCGAGACGCGATCCTTTTAGTCGGGGGAGACAAGTCCAGTGACTGGAACGGCTGGTACAAGGAAGCAATCCCTATTGC
CGAGAAGCGCTACGCGGCCCATCTAGAGGAGCTCGCCGAAGGTCGAGGTCAGGAGAAAGGGAAGAGCTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT140940 WP_004246828.1 NZ_CP044436:3773769-3774089 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT140940 NZ_CP059572:c4275689-4275348 [Actinomadura graeca]
ATGGGTGTCGAGTGGGAGGATCTACGCGACGAGCTTCTCGTCGGCCCCGACGACAAGGCGGAGGTCGCTCGCCGCAGGAA
CAGGCTCCTCGCTGAGGAGCGTGCACATCGACTCGCCGAGGCGAGAAGGCGTCGGCAGCTCACCCAGAAGGACATCGCGG
CCTCGATGGGAGTCACCCAATCGCGGGTCAGCGCCATTGAGCGCGGCAGCCTCGGTCGGGCCGAGCTGGGCACACTGGCT
GCCTATGTTGCGGCTCTCGGGGGACGTCTGGAGATCGTCGCCGACTTCGGAGACGAGAAACTCGTCATCGGCGACAGCGA
TTATCCCGAATCAGGACCCTGA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97