Detailed information of TA system TA140934

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 1531807..1532480
• Replicon: chromosome
• Accession: NZ_CP044434
• Organism: Alicyclobacillus sp. TC

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FY534_RS07555
• Protein ID: WP_203114167.1
• Coordinates: 1531807..1532232 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FY534_RS07560
• Protein ID: WP_203114168.1
• Coordinates: 1532229..1532480 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FY534_RS07525	1527559..1528275	-	717	WP_203114161.1	replication-relaxation family protein	-
FY534_RS07530	1528602..1528913	+	312	WP_203114162.1	hypothetical protein	-
FY534_RS07535	1528944..1529972	-	1029	WP_203114163.1	GGDEF domain-containing protein	-
FY534_RS07540	1530227..1530775	-	549	WP_203114164.1	hypothetical protein	-
FY534_RS07545	1530838..1531092	-	255	WP_203114165.1	hypothetical protein	-
FY534_RS07550	1531106..1531747	-	642	WP_203114166.1	metal-dependent hydrolase	-
FY534_RS07555	1531807..1532232	-	426	WP_203114167.1	type II toxin-antitoxin system VapC family toxin	Toxin
FY534_RS07560	1532229..1532480	-	252	WP_203114168.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
FY534_RS07565	1532555..1532935	-	381	WP_203114169.1	type II toxin-antitoxin system HicB family antitoxin	-
FY534_RS07570	1533028..1533450	-	423	WP_203114170.1	hypothetical protein	-
FY534_RS07575	1533699..1534817	-	1119	WP_203114171.1	hypothetical protein	-
FY534_RS07580	1534795..1535433	-	639	WP_203114172.1	hypothetical protein	-
FY534_RS07585	1535696..1536214	-	519	WP_203114173.1	hypothetical protein	-
FY534_RS07590	1536219..1537370	-	1152	WP_203114174.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1525905..1641354	115449

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-123)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-67)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 16317.90 Da
• Isoelectric Point: 5.0111

>T140934 WP_203114167.1 NZ_CP044434:c1532232-1531807 [Alicyclobacillus sp. TC]
VKYLLDTNVISELVKKEPNSKVIQWIDERDELTLFLSVLTLGELQKGIAKLKDASRIRRLQEWVQHDLTQRFAGRILPID
LDVMLCWGQLQGESEKEGIRLPVIDSLIAATAMTYHLIVVTRNVRDLERCQAEVYNPWECD

Nucleotide

• Length: 426 bp

>T140934 NZ_CP059571:c692242-691745 [Neisseria bacilliformis]
GTGAAAACCGTTCCGCTCGATACCGCCAAGCATAACCGGCAGGGCTTTGATTGCGGCGTCGAAGCCTTAAACCTGTTCCT
GCAACGCACCGCCAACCAACAGGCGGCAAAAAACCACGCCCGCACCTATGTGCTGGAAGACGAAGCCGACGGCACACGGA
TAGCGGGTTTCTACACCCTGACCATGATCCAATTCGAGCTTTCGCAAATTCCGCCTCAGTTGCAGAAAAAGCACCGTCCC
GTGCAGGCTGCCGCCCTGATTGCCAGGCTTGCCGTCGATACCGCGTATCAGGGCAAAGGCTTCGGCGGCTTTCTGCTGCA
TGACGCGCTGTGCCGCCTGTATCAGGCCGCCTACCTCGTGGGCTTCCCCGTCGTGTTTGTCGATGCCAAAGACGGTATGG
CGGATTTCTACCGCCGCTACGGCTTTGCCGATGCCGCCGCAAACCGACTATACATCACGGTTGAAACCATACGGCAGGCA
ATAGCAAAGACGGCCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9760.06 Da
• Isoelectric Point: 5.1695

>AT140934 WP_203114168.1 NZ_CP044434:c1532480-1532229 [Alicyclobacillus sp. TC]
MSSEWQIQEAKNRLSQLIKDVSRDGPQIITVRGKPTAVLLSIEEYRRLTHSPIKLTEFFRESPLHDEELLIERNSDWGRE
VEL

Nucleotide

• Length: 252 bp

>AT140934 NZ_CP059571:c692514-692239 [Neisseria bacilliformis]
ATGACTGCCGCCACCCATACCCGCGTTACCGCCCGCATCGATCCCGCCACCCAATCTCTGCTCAACCGCGCGGCCGAAGC
CGCAGGCATTCCCACCATCAACGCCTTTGTTTTGGGCGCAGCCGTGGAGAAAGCCAAAGCCATTTTGCAGCAGGAAGAAA
TCATCCGGCTCAATGCCGATTCGTCCCTGCGACTGTTGGATGCGCTGGAAAACCCGCCCGCACCCAACCGGCACTTGTCC
GAGCTGTTCCGCAAACACCGAAGCGAGTGCCCGTGA