Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1704915..1705479 Replicon chromosome
Accession NZ_CP044427
Organism Ornithinimicrobium pratense strain W204

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag FY030_RS07740 Protein ID WP_158061010.1
Coordinates 1705132..1705479 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag FY030_RS07735 Protein ID WP_141338789.1
Coordinates 1704915..1705145 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FY030_RS07705 1700264..1701856 + 1593 WP_158061005.1 flotillin family protein -
FY030_RS07710 1701947..1702159 - 213 WP_192498767.1 hypothetical protein -
FY030_RS07715 1702180..1702491 + 312 WP_158061006.1 RNA methyltransferase -
FY030_RS07720 1702713..1703270 + 558 WP_202879783.1 cysteine hydrolase -
FY030_RS07725 1703318..1704568 - 1251 WP_158061008.1 multidrug effflux MFS transporter -
FY030_RS07730 1704689..1704877 + 189 WP_158061009.1 DUF3817 domain-containing protein -
FY030_RS07735 1704915..1705145 + 231 WP_141338789.1 ribbon-helix-helix domain-containing protein Antitoxin
FY030_RS07740 1705132..1705479 + 348 WP_158061010.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
FY030_RS07745 1705538..1706068 + 531 WP_158061011.1 DinB family protein -
FY030_RS07750 1706300..1707412 + 1113 WP_158061012.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
FY030_RS07755 1707489..1707935 - 447 WP_158061013.1 hypothetical protein -
FY030_RS07760 1708347..1708787 + 441 WP_158061014.1 hypothetical protein -
FY030_RS07765 1709040..1710242 + 1203 WP_202879784.1 IS110 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12502.50 Da        Isoelectric Point: 11.1582

>T140933 WP_158061010.1 NZ_CP044427:1705132-1705479 [Ornithinimicrobium pratense]
MLRGEVLLVDLDPVRGSEANKRRPAVLVSNDRANTMAQRLGRGVVTLVPVTSNVERVFPFQVLLPADETGLRVDSKAQAE
QVRSVAVERVGSAVGRVPPRLMAAVDEAVRIHLQL

Download         Length: 348 bp

>T140933 NZ_CP059570:c2481112-2480723 [Neisseria dentiae]
ATGAAATACCTGCTCGACACCAACGCTGTAATTGCCATCTTGAACCGCAACACTGATTTCATCCAACGCTTAAAACAACA
CACCCCTGCCGATTTCGCCCTTTCCGCGATTACTTGGTTTGAACTGCACTACGGTGCGCACAAAAGTCAAAAAGCGGCAG
AAAATCTGGCCAAGCTGGAAAAACTTGCTTTCAATATCCTGCCGTTTTCACAGCAGGACGCACAAACAGCCGGAAAAATC
CGCAGCGATTTAGCCAAACAAGGCACTCCCATCGGCAGTTACGACATCTTGATTGCCGCCCAAGCCTTATCAAATCAACT
GGTTTTGATTACCCATAATGTGCGCGAGTTTGAGCGGGTGGAAGGGTTATGGGTGGAGGATTGGGAGTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8169.85 Da        Isoelectric Point: 3.8308

>AT140933 WP_141338789.1 NZ_CP044427:1704915-1705145 [Ornithinimicrobium pratense]
MKVSVSLSEEDLAALDRYVEEAGLESRSAAVQQAIRRLQDPQLEAAYAAAWEEWAVAGDEDAWASASSDGLTDAAR

Download         Length: 231 bp

>AT140933 NZ_CP059570:c2481351-2481109 [Neisseria dentiae]
ATGACCACCGCAAAATTATTTTGGAACGGCAATTCGCAAGCGGTCCGTCTTCCCAAAGAATTCCGCTTTGAAGGCAAAGA
AGTCAAAATCAGTAAGCAAGGAAATCAAGTGATTATCGAACCTTTAGTTACCGATTGGGATTGGCTCGACAGCTTGGGTG
AGCCGGATGCCAGTTTTGAAACCGCCGTTAATGAGATACGGGTAGAAGCAGCACAAGAGCGTGATTGGAGTGTTTTTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References