Detailed information of TA system TA140932

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1842337..1842998
• Replicon: chromosome
• Accession: NZ_CP044426
• Organism: Paracoccus pantotrophus strain DSM 2944

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: ESD82_RS19565
• Protein ID: WP_197029493.1
• Coordinates: 1842597..1842998 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A495PKQ6
• Locus tag: ESD82_RS19560
• Protein ID: WP_028710954.1
• Coordinates: 1842337..1842600 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ESD82_RS19540	1839401..1839784	-	384	WP_028710950.1	hypothetical protein	-
ESD82_RS19545	1839898..1840191	-	294	WP_028710951.1	helix-turn-helix domain-containing protein	-
ESD82_RS19550	1840173..1840502	-	330	WP_028710952.1	type II toxin-antitoxin system RelE/ParE family toxin	-
ESD82_RS19555	1840599..1841951	-	1353	WP_028710953.1	hypothetical protein	-
ESD82_RS19560	1842337..1842600	+	264	WP_028710954.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
ESD82_RS19565	1842597..1842998	+	402	WP_197029493.1	type II toxin-antitoxin system VapC family toxin	Toxin
ESD82_RS19570	1843088..1845526	-	2439	WP_147427564.1	DEAD/DEAH box helicase	-
ESD82_RS19575	1845565..1847070	-	1506	WP_114669424.1	TniQ family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1839898..1849044	9146

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (16-53)

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14092.24 Da
• Isoelectric Point: 5.1698

>T140932 WP_197029493.1 NZ_CP044426:1842597-1842998 [Paracoccus pantotrophus]
MTLYMLDTNIVSDLLRHPDGSAAKRIAEVGPDAICVSIITAAELRYGCARKGSAKLLAHVEAILESVQILALDVPADAEY
GSIRAELEAAGKPIGPNDLLIAAHACAAGAILVTDNTGEFSRVRGLRVENWIR

Nucleotide

• Length: 402 bp

>T140932 NZ_CP059570:c1426123-1425872 [Neisseria dentiae]
ATTTCGGAGTTTTTATTTGAATTCACTATAATATTCAGCCGCCCCGTATCCGGCGGCATCAAATGGGCGGATATTGAAGT
TCTGTTTGTCGAATTGGGCGCGGAAATACAAGAAAGAGAAGGTAGCCGTGTGGCTGTAATCCTTTTCGGGCAAGTGAAAG
TGTTTCATAGGCCGCATCCAAGCCCTGATACAGATAAAGGCGCAGTTGCGAGCGTGCGTAAATGGTTGGAAGAAAACGGA
GTAAAGCCATGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9997.39 Da
• Isoelectric Point: 4.8605

>AT140932 WP_028710954.1 NZ_CP044426:1842337-1842600 [Paracoccus pantotrophus]
MPRPQPHSEPREAKLFRNNKSQAVRIPADFEMPGDRVNIYRDGNRLIIEPVRRKNLLEVLAGLDPLGPEDQFPDVDETLL
PAREIDL

Nucleotide

• Length: 264 bp

>AT140932 NZ_CP059570:c1425875-1425540 [Neisseria dentiae]
ATGAACAATGTAATGGAAATCAACGGTCATAAAGCTATTATTCAATACGACCCTGAAACCGAGTTACTGCGCGGCGAGTT
TGTCGGCCTTAACGGTGGGGCGGATTTTTACGCCGATAACGTGGCAGACTTGCACAAAGAGGGGGAGGCCAGTTTGGCGG
TTTTTCTCGATGTGTGCAAAGAAAAAGGTATTGAGCCGTATAAACAGTATTCAGGCCGCTTTAATGTGCGGGTAAGCCCT
GAAACCCATGCGGCGGCGGCGGCGGCGGCGGCGGCGCAAAATATCAGCCTGAATGAATGGGTAAACCGTGCAATCAGCCA
ATCCGCCCATGCCTGA

Structures

Antitoxin

• AlphaFold DB: A0A495PKQ6