Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1297674..1298203 Replicon chromosome
Accession NZ_CP044426
Organism Paracoccus pantotrophus strain DSM 2944

Toxin (Protein)


Gene name parE Uniprot ID A0A1I5JV80
Locus tag ESD82_RS16940 Protein ID WP_024845134.1
Coordinates 1297674..1297961 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1I5JVF8
Locus tag ESD82_RS16945 Protein ID WP_024845133.1
Coordinates 1297958..1298203 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESD82_RS16910 1293732..1294088 - 357 WP_147427763.1 arsenate reductase (glutaredoxin) -
ESD82_RS16915 1294099..1294635 - 537 WP_208852064.1 arsenate reductase ArsC -
ESD82_RS16920 1294641..1295162 - 522 WP_051419865.1 hypothetical protein -
ESD82_RS16925 1295205..1295543 + 339 WP_028710997.1 metalloregulator ArsR/SmtB family transcription factor -
ESD82_RS16930 1295687..1296859 + 1173 WP_147427762.1 ATP-binding protein -
ESD82_RS16935 1297083..1297655 - 573 WP_143091279.1 hypothetical protein -
ESD82_RS16940 1297674..1297961 - 288 WP_024845134.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ESD82_RS16945 1297958..1298203 - 246 WP_024845133.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
ESD82_RS16950 1298308..1299669 - 1362 WP_028710598.1 plasmid recombination protein -
ESD82_RS16955 1299662..1300519 - 858 WP_028710599.1 hypothetical protein -
ESD82_RS16965 1301001..1301798 + 798 WP_024845130.1 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB -
ESD82_RS16970 1301898..1302311 + 414 WP_024845129.1 YHS domain-containing protein -
ESD82_RS16975 1302495..1302947 + 453 WP_024845128.1 CoA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10744.14 Da        Isoelectric Point: 6.0719

>T140931 WP_024845134.1 NZ_CP044426:c1297961-1297674 [Paracoccus pantotrophus]
MKALAFTVAATVDLEDIWDYTEGEWGLAQARRYVQELRDTCHALASGERRGRSVDVRPGYLKCLSGSHVIFFRDLGDTLE
IVRILHGAQDAERHL

Download         Length: 288 bp

>T140931 NZ_CP059569:c1811161-1810643 [Kingella oralis]
ATGAACGATAACCCAGCCGTGGTGGTTTTAAATAAGGGCGTTGAGCCATTAAATGAAACGCACAACCGAAAGGGTTTTGA
TTGTGGCGTGCCAGCATTAAATGATTTTTTGCAAAAGTTTGCTGGGCAGAAATCCAATAGAAATCAGGCGCAGACTTATG
TTTTATCGGCTGATGACAATGAAACCATTATTGGCTATTTCACGCTTACCATGACGCGGTTTAATTGGCATGAGATAGTG
GGCAAGAAAAGTAAAACGGTAGATACGGCTGCGCTGATTGCCCGTTTGGCAGTAGATAAGCGATTTACCGGACAGGGCGT
AGGATTGTTTTTGTTGCGTACTGCTTTGGAAAAATTGATTATTGCCAATGATATTTTGGGCGTTCCGATTATTGTTGTAG
ATGCCAAAGATGGCGTTTCAGCATTTTATGAGACGGTTGGATTTCAATTTTTAGAACAGGGCAGTAGCAGGCTATTTATT
ACAATGGAAACCATTTTGAATAGCCAAAAGATTAAATAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8709.78 Da        Isoelectric Point: 6.4652

>AT140931 WP_024845133.1 NZ_CP044426:c1298203-1297958 [Paracoccus pantotrophus]
MSRNTSVSLGDHFVSFIDAQVKGGRYGSASDVVRAGLRLLEEHETKVKALEAALIAGEESGRAEGFDLDQFIARKMAGRN
A

Download         Length: 246 bp

>AT140931 NZ_CP059569:c1811435-1811151 [Kingella oralis]
ATGACTTCAACTGCTCCGCGTATTACTGCGCGGATTGATGTGCAAACACAAGATTTATTAAAAGAAGCTGCCCAGTTGGC
AGGAATTTCCAGCATCAATTCGTTTGTTTTGCAGGCAGCTTTAAAAGAAGCGAAAGCGATTATTGCGCAGGAGCAAACCA
TTCAATTAAGCCAAGAAGCCAGCTTGCGTTTAATGGACGCGCTAAATAATCCCCCAGAGCCTAATCCAAAACTACGCCAA
CTGTTTCAAACCAATTTTGACGAAGTGAACGTGTATGAACGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5JV80

Antitoxin

Source ID Structure
AlphaFold DB A0A1I5JVF8

References