Detailed information of TA system TA140929

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbE-relB/ParE-YafN
• Location: 94390..94927
• Replicon: plasmid pPAN1
• Accession: NZ_CP044424
• Organism: Paracoccus pantotrophus strain DSM 2944

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: -
• Locus tag: ESD82_RS07820
• Protein ID: WP_104491150.1
• Coordinates: 94390..94692 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: ESD82_RS07825
• Protein ID: WP_104491151.1
• Coordinates: 94682..94927 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ESD82_RS07795	90114..92135	-	2022	WP_147429450.1	type I restriction-modification system subunit M	-
ESD82_RS07800	92728..92973	+	246	WP_140848566.1	type II toxin-antitoxin system VapB family antitoxin	-
ESD82_RS07805	92973..93398	+	426	WP_167521730.1	type II toxin-antitoxin system VapC family toxin	-
ESD82_RS07810	93408..93590	+	183	WP_116171356.1	hypothetical protein	-
ESD82_RS21760	93587..93760	+	174	WP_166436162.1	hypothetical protein	-
ESD82_RS07815	93762..93956	-	195	WP_116171357.1	hypothetical protein	-
ESD82_RS07820	94390..94692	-	303	WP_104491150.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ESD82_RS07825	94682..94927	-	246	WP_104491151.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
ESD82_RS07830	94949..95245	-	297	WP_147429448.1	hypothetical protein	-
ESD82_RS07835	95605..96750	+	1146	WP_147429447.1	aldehyde dehydrogenase family protein	-
ESD82_RS07840	96772..97287	-	516	WP_051416320.1	hypothetical protein	-
ESD82_RS07845	97463..98149	+	687	WP_028714065.1	cytochrome c-550 PedF	-
ESD82_RS07850	98154..98945	+	792	WP_036714371.1	quinoprotein dehydrogenase-associated SoxYZ-like carrier	-
ESD82_RS07855	98942..99886	+	945	WP_028714064.1	quinoprotein relay system zinc metallohydrolase 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..99949	99949

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-70)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 11641.46 Da
• Isoelectric Point: 10.5908

>T140929 WP_104491150.1 NZ_CP044424:c94692-94390 [Paracoccus pantotrophus]
MTFELKFLPSALKEWKKLGATLREQFRKKLAERLEQPRVPADALHGLEDHYKIKLRSAGYRLVYRVEDAEITVTVVAVGR
RERSEVYKAASARRDDRPKS

Nucleotide

• Length: 303 bp

>T140929 NZ_CP059569:1697793-1698200 [Kingella oralis]
ATGATGTATATGCTAGACACCAATATCTTGATTTATATTCAGAAAAACAACCCGCCTGCGGTGCGCGAGAAAATCAACCG
CCTGCCGAGCCATGCCAAGCTGTGCATGAGTTTTGTGAGCTATGCCGAATTGTTAAGCGGCGCGCAAGGCAGCCGAAACC
CTGAAAAAGCGCGCGAAAACATCGCCCGCTTGGTGCAGATTGTGTCCGTTTTGCTGCCTGAAACGCCGATTTGCGAACAC
TATGCGCGCTGGCGCGATGCGCTGAAACGGCAAGGGGCGATGATTGGCGGCAATGATTTGTGGATTGCGGCGCACGCCTT
GGCGGCGGATGCGGTTTTGGTAACGCACAATACGAAAGAATTTGCGCAGATTGGCGATTTGAAATGGGAGGATTGGACGG
CGCAATAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8844.18 Da
• Isoelectric Point: 4.1265

>AT140929 WP_104491151.1 NZ_CP044424:c94927-94682 [Paracoccus pantotrophus]
MQRVEAQIAVSVSDLKKSPTAIMDQAQGEAVAVLNHNRVMAYMVPADVYEAMMERLDDLALVDVIKARADETPISVGLDD
L

Nucleotide

• Length: 246 bp

>AT140929 NZ_CP059569:1697554-1697796 [Kingella oralis]
ATGCTAACCAAAATCTTCCAAAGCGGCGGCAGCCAAGCGGTTCGCATTCCGAAAGACTTTCGTTTTAATGGCGACACGGT
GGAAATTTTCCGCGCCGAAAACGGCGATGTGGTGTTGCGCGCGCCGCAAAGCAGCCAGCGTGGCGACGCACTGTTTGCGG
TGCTGGCGCAGTTTGATGACGACTTTATCGCCGGCGTGGCAGCGCGCGATAACGAGCCGCCGCAGGAGCGTGATGCGCTA
TGA