Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 29237..29849 Replicon plasmid pPAN1
Accession NZ_CP044424
Organism Paracoccus pantotrophus strain DSM 2944

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag ESD82_RS07535 Protein ID WP_123130490.1
Coordinates 29454..29849 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ESD82_RS07530 Protein ID WP_123130489.1
Coordinates 29237..29464 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ESD82_RS07515 25451..26662 - 1212 WP_032490181.1 replication initiation protein RepC -
ESD82_RS07520 26845..27837 - 993 WP_123130498.1 plasmid partitioning protein RepB -
ESD82_RS07525 27837..29021 - 1185 WP_123130488.1 plasmid partitioning protein RepA -
ESD82_RS07530 29237..29464 + 228 WP_123130489.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
ESD82_RS07535 29454..29849 + 396 WP_123130490.1 PIN domain-containing protein Toxin
ESD82_RS07540 29928..30812 - 885 WP_123130491.1 recombinase family protein -
ESD82_RS07545 31039..32106 + 1068 WP_147429486.1 hypothetical protein -
ESD82_RS07550 32198..32722 - 525 WP_167521732.1 PIN domain-containing protein -
ESD82_RS07555 32709..32966 - 258 Protein_30 transposase -
ESD82_RS07560 33079..33159 + 81 Protein_31 IS5/IS1182 family transposase -
ESD82_RS07565 33268..34791 - 1524 WP_147429484.1 aldehyde dehydrogenase (NADP(+)) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..99949 99949
- flank IS/Tn - - 32703..32966 263


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-113)

Antitoxin

SpoVT-AbrB domain

(5-45)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14300.34 Da        Isoelectric Point: 4.1653

>T140928 WP_123130490.1 NZ_CP044424:29454-29849 [Paracoccus pantotrophus]
MSAEFADTNVVLYLLDDGPKADRAELILGQGPRISVQVLNETLVNCRRKAGLSWEEAGTFLEGVRALCPVEDLTLQTHDV
GRALAERYGFSIYDAMIVASALVVGCTTLWSEDMQDGLLVEGQLRIVNPFA

Download         Length: 396 bp

>T140928 NZ_CP059569:459901-460308 [Kingella oralis]
ATGTTGAAATATATGCTTGATACCAATATCGTGATTTATGTGATGAAACAAAATCCGATTGAGGTATTGGATACATTTAA
CCGCCATGCTGCGCATCTTTGTATCAGTAGTATTACTGCCGCAGAATTGTATTATGGCGCAGAAAAAAGCAGCTTTCCTG
AACGCAATCTACAACGTGCGGAAGATTTTATGTCGCGCTTGCAAGTTTTGTCATATGGCATAAAAGCTGCCACTCATTTT
GGCAATATTCGTTATGAACTACAAAAACAAGGGCAACTAATTGGCGAAAATAATATGCACATCGCCGCTCATGCCCGCAG
CGAAGGGTTGGTTTTAGTGAGCAATAATTTACGTGAATTTGAGCGGGTTGCGGGGCTAAGGTTTGAAAATTGGGTAACTT
CACACTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8531.80 Da        Isoelectric Point: 10.7157

>AT140928 WP_123130489.1 NZ_CP044424:29237-29464 [Paracoccus pantotrophus]
MQVAKWGNSLAVRLPAELVRELGLKEGDQIDLVKDDGQVRVRRLARADEVLTGLRRFRGKLPAAERLSREDAHER

Download         Length: 228 bp

>AT140928 NZ_CP059569:459713-459898 [Kingella oralis]
TTGCCTTATTCCGCCCGATTTGATGAACACGTTACTCATGTCAATGTGCGCGTAGTCGGCAACGAGCGCATTATCAGCCC
CGCTAATCAAGTGTGGGACAGCTTCTTTTTAAGCGGCAACACCGCCAGCGCAGATTTTATGGCAGAGCGCGAAACGGCAG
TGCAGCCTGAACGAGATGGTTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References